Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

377 questions · 736 findings · 60 reviews · Dental caries

No studies found 17 · 2.3%GRADE not reported 563 · 76.5%Very low 39 · 5.3%Low 47 · 6.4%Moderate 50 · 6.8%High 20 · 2.7%

Resin infiltration + 5% NaF varnish vs Sealant

Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth)

Resin infiltration + 5% NaF varnish may not differ from Sealant for arrest or reversal of approximal carious lesions (RR 1.91, 95% CI 0.48 to 7.52; very low certainty).

1 finding from 1 review

0.2% NaF mouthrinse + supervised toothbrushing vs Sealants plus fluoride varnish (with or without restorations)

Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)

0.2% NaF mouthrinse + supervised toothbrushing was probably less effective than Sealant + 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 0.58, 95% CI 0.43 to 0.79; moderate certainty).

1 finding from 1 review

1.23% APF gel vs Fluoride varnish

Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)

1.23% APF gel may not differ from 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 1.08, 95% CI 0.83 to 1.4; low certainty).

1 finding from 1 review

0.2% NaF mouthrinse + supervised toothbrushing vs Fluoride varnish

Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)

0.2% NaF mouthrinse + supervised toothbrushing may not differ from 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 0.99, 95% CI 0.84 to 1.15; low certainty).

1 finding from 1 review

Fluoride varnish vs no treatment

Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)

5% NaF varnish may not differ from no treatment for arrest or reversal of root carious lesions (RR 2.96, 95% CI 0.27 to 32.26; very low certainty).

1 finding from 1 review

1% chlorhexidine + 1% thymol varnish vs Fluoride varnish

Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)

1% chlorhexidine + 1% thymol varnish may not differ from 5% NaF varnish for arrest or reversal of root carious lesions (RR 0.57, 95% CI 0.04 to 8.69; very low certainty).

1 finding from 1 review

Fluoride varnish vs no treatment

Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth)

5% NaF varnish may not differ from no treatment for arrest or reversal of approximal carious lesions (RR 2.29, 95% CI 0.74 to 7.1; very low certainty).

1 finding from 1 review

Resin infiltration vs Sealant

Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth)

Resin infiltration may not differ from Sealant for arrest or reversal of approximal carious lesions (RR 0.88, 95% CI 0.4 to 1.91; very low certainty).

1 finding from 1 review

1.23% APF gel vs Resin infiltration + 5% NaF varnish

Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)

1.23% APF gel may be less effective than Resin infiltration + 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 0.67, 95% CI 0.45 to 0.99; low certainty).

1 finding from 1 review

38% SDF + potassium iodide solution (applied annually) vs 5,000-ppm F (1.1% NaF) toothpaste or gel

Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)

38% SDF + potassium iodide solution (applied annually) may not differ from 5,000-ppm F (1.1% NaF) toothpaste or gel for arrest or reversal of root carious lesions (RR 0.9, 95% CI 0.22 to 3.62; very low certainty).

1 finding from 1 review

1.23% APF gel vs Sealants plus fluoride varnish (with or without restorations)

Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)

1.23% APF gel may be less effective than Sealant + 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 0.64, 95% CI 0.44 to 0.92; low certainty).

1 finding from 1 review

0.2% NaF mouthrinse + supervised toothbrushing vs 1.23% APF gel

Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)

0.2% NaF mouthrinse + supervised toothbrushing may not differ from 1.23% APF gel for arrest or reversal of occlusal carious lesions (RR 0.91, 95% CI 0.68 to 1.22; low certainty).

1 finding from 1 review

Resin infiltration + 5% NaF varnish vs Sealant

Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)

Resin infiltration + 5% NaF varnish was probably more effective than Sealant for arrest or reversal of occlusal carious lesions (RR 1.61, 95% CI 1.16 to 2.24; moderate certainty).

1 finding from 1 review

Fluoride varnish vs Sealants plus fluoride varnish (with or without restorations)

Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)

5% NaF varnish was probably less effective than Sealant + 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 0.59, 95% CI 0.45 to 0.76; moderate certainty).

1 finding from 1 review

1% chlorhexidine + 1% thymol varnish vs no treatment

Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)

1% chlorhexidine + 1% thymol varnish may not differ from no treatment for arrest or reversal of root carious lesions (RR 1.67, 95% CI 0.44 to 6.31; very low certainty).

1 finding from 1 review

Resin infiltration + 5% NaF varnish vs no treatment

Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth)

Resin infiltration + 5% NaF varnish may be more effective than no treatment for arrest or reversal of approximal carious lesions (RR 4.59, 95% CI 1.01 to 20.88; very low certainty).

1 finding from 1 review

Sealant + 5% NaF varnish vs Sealant

Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)

Sealant + 5% NaF varnish was probably more effective than Sealant for arrest or reversal of occlusal carious lesions (RR 1.69, 95% CI 1.26 to 2.27; moderate certainty).

1 finding from 1 review

Resin infiltration vs Resin infiltration + 5% NaF varnish

Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth)

Resin infiltration may not differ from Resin infiltration + 5% NaF varnish for arrest or reversal of approximal carious lesions (RR 0.46, 95% CI 0.09 to 2.23; very low certainty).

1 finding from 1 review

1.23% APF gel + oral health education vs Oral health education

Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth)

1.23% APF gel + oral health education was probably more effective than Oral health education for arrest or reversal of facial/lingual carious lesions (RR 2.47, 95% CI 1.95 to 3.13; moderate certainty).

1 finding from 1 review

0.2% NaF mouthrinse + supervised toothbrushing vs Resin infiltration + 5% NaF varnish

Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)

0.2% NaF mouthrinse + supervised toothbrushing was probably less effective than Resin infiltration + 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 0.61, 95% CI 0.43 to 0.85; moderate certainty).

1 finding from 1 review