Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

332 questions · 398 findings · 53 reviews

No studies found 114 · 28.6%GRADE not reported 115 · 28.9%Very low 66 · 16.6%Low 69 · 17.3%Moderate 30 · 7.5%High 4 · 1%

Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or younger (permanent dentition)
3 findings from 1 review

Micro-invasive treatment (proximal sealing or resin infiltration): resin sealant, glass ionomer sealant, polyurethane/adhesive patch, or resin infiltration vs Non-invasive / control treatment

Change in decayed, missing and filled (DMF/dmf) figures at surface, tooth and whole mouth level · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…

The review found no eligible studies for this question.

1 finding from 1 review

Rapid COJEC vs standard induction therapies

Late non‐hematological toxicities: any complication, renal toxicity (Glomerular Filtration Rate < 80 ml/min per body surface area of 1.73 m2), ototoxicity (Brock grade 1 to 4), endocrine complications (see table of included studies for included di... · patients with high‐risk neuroblastoma
1 finding from 1 review

Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan

Plaque · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…

Triclosan/copolymer-containing fluoride toothpaste probably leads to lower plaque severity at 6 to 7 months (Plaque Severity Index, proportion… compared with fluoride toothpaste without triclosan (moderate certainty).

1 finding from 1 review

Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan

Coronal caries increment · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…

Triclosan/copolymer-containing fluoride toothpaste leads to lower coronal caries increment at 24 to 36 months (decayed filled… compared with fluoride toothpaste without triclosan (high certainty).

1 finding from 1 review

Silver alloyed catheter vs silicone catheter

urinary tract infections Bacterial biofilm on the surfaces of catheters. UTI was defined as uropathogenic colonisation of urinary catheter. · patients with long‐term bladder drainage in adults

Silver alloyed catheter showed no clear difference in urinary tract infections Bacterial biofilm on the surfaces of… compared with silicone catheter (low certainty).

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs Topical fluoride (fluoride rinse, varnish or toothpaste)

Caries increment in permanent teeth · Children and adolescents aged 16 years or less
2 findings from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs No fluoride supplement (placebo or no treatment)

Caries increment in permanent teeth · Children and adolescents aged 16 years or less
2 findings from 1 review

Compomer (Dyract) vs Amalgam (Tytin)

Surface texture failures at 24 months · Children aged 12 years or younger with tooth decay involving at least one tooth in the primary dentition, symptomatic or symptom free

Compomer (Dyract) showed no clear difference in surface texture failures at 24 months compared with amalgam (Tytin); GRADE not reported.

1 finding from 1 review