Findings

What do systematic reviews say?

303 questions · 322 findings · 45 reviews

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No studies found 31 · 9.6%GRADE not reported 22 · 6.8%Very low 99 · 30.7%Low 95 · 29.5%Moderate 68 · 21.1%High 7 · 2.2%

SPRM vs leuprolide acetate

Adverse effects: SPRM‐associated endometrial changes · uterine fibroids

SPRM probably leads to higher adverse effects: SPRM‐associated endometrial changes compared with leuprolide acetate (moderate certainty).

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 10.45 [5.38, 20.33]
1 study · 301 participants
Moderate

SPRM vs placebo

Quality of life: change in health‐related quality of life score · women with uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 200 participants
Moderate

SPRM vs placebo

Abnormal uterine bleeding: change in menstrual blood loss · women with uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 310 participants
Moderate

SPRM vs placebo

Abnormal uterine bleeding: amenorrhoea · women with uterine fibroids

SPRM probably leads to higher abnormal uterine bleeding: amenorrhoea compared with placebo (moderate certainty).

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 82.5 [37.1, 183.9]
7 studies · 590 participants
Moderate

SPRM vs placebo

Pelvic pain · women with uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 629 participants
GRADE not reported

SPRM vs placebo

Adverse effects: SPRM‐associated endometrial changes · women with uterine fibroids

SPRM may leads to higher adverse effects: SPRM‐associated endometrial changes compared with placebo (low certainty).

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 15.12 [6.45, 35.47]
5 studies · 405 participants
Low

SPRM vs leuprolide acetate

Quality of life: change in symptom severity score · uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 281 participants
Moderate

SPRM vs leuprolide acetate

Quality of life: change in health‐related quality of life score · uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 281 participants
Moderate

SPRM vs leuprolide acetate

Abnormal uterine bleeding: change in menstrual blood loss · uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 281 participants
Low

Intervention not reported

Systolic blood pressure · People with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of beta‐1 selective beta blockers for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
47 studies · 5246 participants
Low

Intervention not reported

Diastolic blood pressure · People with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of beta‐1 selective beta blockers for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
48 studies · 5316 participants
Low

Intervention not reported

Heart rate · People with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of beta‐1 selective beta blockers for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
33 studies · 3407 participants
Low

Intervention not reported

Pulse pressure · People with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of beta‐1 selective beta blockers for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
47 studies · 5246 participants
Very low

Intervention not reported

WDAE · People with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of beta‐1 selective beta blockers for primary hypertension 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 2618 participants
Low

SSRIs or SNRIs vs placebo

Migraine frequency Number of attacks · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 113 participants
Low

SSRIs or SNRIs vs amitriptyline

Migraine duration Hours · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 104 participants
Low

SSRIs or SNRIs vs amitriptyline

Symptomatic/analgesic medication use for acute headache attacks · patients for whom migraine preventive interventions are indicated

The review found no eligible studies for this question.

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SSRIs or SNRIs vs amitriptyline

Migraine index · patients for whom migraine preventive interventions are indicated

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Very low

SSRIs or SNRIs vs amitriptyline

Quality of life · patients for whom migraine preventive interventions are indicated

The review found no eligible studies for this question.

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SSRIs or SNRIs vs amitriptyline

Participants who withdraw because of an adverse event or any other reason · patients for whom migraine preventive interventions are indicated

SSRIs or SNRIs showed no clear difference in withdrawn (for any reasons and due to adverse events) compared with amitriptyline (low certainty).

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
OR 0.39 [0.1, 1.5]
1 study · 64 participants
Low