Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

327 questions · 337 findings · 47 reviews · Headline outcomes only

No studies found 69 · 20.5%GRADE not reported 35 · 10.4%Very low 49 · 14.5%Low 73 · 21.7%Moderate 63 · 18.7%High 48 · 14.2%

Some components of shared decision‐making, including clarification of values and preferences, vs control

Confidence in the decision made · women aged 38 to 71 years at average to moderate risk of breast cancer

It is very uncertain whether some components of shared decision‐making, including clarification… changes confidence in the decision made compared with control (very low certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

False‐positive rate · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography leads to higher false‐positive rate compared with mammography alone (high certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

False‐negative rate · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography probably leads to lower false‐negative rate compared with mammography alone (moderate certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Rate of biopsies · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography leads to higher rate of biopsies compared with mammography alone (high certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Incremental cancer detection: cohort studies · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography leads to higher incremental cancer detection: RCT compared with mammography alone (high certainty).

2 findings from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Incremental detection of invasive cancers · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography showed no clear difference in incremental detection of invasive cancers: RCT compared with mammography alone (low certainty).

2 findings from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Interval cancer · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography leads to lower interval cancer compared with mammography alone (high certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Lymph node status · s of women with dense and non‐dense breasts

Mammography in combination with breast ultrasonography probably leads to lower lymph node status compared with mammography alone (moderate certainty).

1 finding from 1 review

Intervention not reported

Index test · children with close tuberculosis contacts Index tests: groups of multiple symptoms Role: an initial test Threshold for index tests: any 1…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Specificities 99% and 100% · children evaluated in inpatient or outpatient settings Index tests: Xpert MTB/RIF Role: an initial test Threshold for index tests: an…
1 finding from 1 review

Intervention not reported

≥ 1 of cough, fever, or poor weight gain · children with close tuberculosis contacts Index tests: groups of multiple symptoms Role: an initial test Threshold for index tests: any 1…
1 finding from 1 review

Intervention not reported

≥ 1 of cough, fever, or decreased playfulness · children with close tuberculosis contacts Index tests: groups of multiple symptoms Role: an initial test Threshold for index tests: any 1…
1 finding from 1 review

Intervention not reported

≥ 1 of cough, fever, poor weight gain, or tuberculosis close contact (WHO 4‐symptom symptom screen) · children with close tuberculosis contacts Index tests: groups of multiple symptoms Role: an initial test Threshold for index tests: any 1…
1 finding from 1 review

Intervention not reported

Estimation (95% Cl) · children with close tuberculosis contacts Index test: abnormal chest radiography Role: an initial test Threshold for index tests: author…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Pooled sensitivity 87% (75% to 93%) · children with close tuberculosis contacts Index test: abnormal chest radiography Role: an initial test Threshold for index tests: author…
1 finding from 1 review

Intervention not reported

Pooled specificity 99% (68% to 100%) · children with close tuberculosis contacts Index test: abnormal chest radiography Role: an initial test Threshold for index tests: author…
1 finding from 1 review