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What do systematic reviews say?

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Evidence found and GRADE certainty

771 questions · 791 findings · 66 reviews

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No studies found 207 · 26.2%GRADE not reported 47 · 5.9%Very low 172 · 21.7%Low 211 · 26.7%Moderate 107 · 13.5%High 47 · 5.9%

MSCs vs placebo or control

Incidence of acute GvHD (prophylactic trials) · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

MSCs showed no clear difference in incidence of acute GvHD (prophylactic trials) compared with control/placebo (low certainty).

1 finding from 1 review

MSCs vs placebo or control

Incidence of chronic GvHD (prophylactic trials) · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

MSCs may leads to lower incidence of chronic GvHD (prophylactic trials) compared with control/placebo (low certainty).

1 finding from 1 review

Intervention not reported

Utilisation of research (4 obstetric practices: use of polyglycolic acid sutures, ventouse for instrumental delivery, prophylactic antibiotics in caesarean section, and prophylactic corticosteroids in preterm deliveries).2 · Healthcare decision makers, health system managers or policy makers
1 finding from 1 review

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Requirement of other courses of antibiotics · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in requirement of other courses of antibiotics compared with continuation (low certainty).

1 finding from 1 review

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Incidence of S pneumoniae Confirmed bacterial infection · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in incidence of S pneumoniae Confirmed bacterial infection compared with continuation (low certainty).

1 finding from 1 review

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Nausea and vomiting · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in adverse effects: incidences of nausea and vomiting compared with continuation (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Adverse event nausea and vomiting (0 to 24 hours) · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in gastrointestinal side effects (nausea and/or vomiting) compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Complete abortion rate · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in complete abortion rate compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Unscheduled contact with care · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in unscheduled contact with care compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Patient satisfaction with abortion care overall ‐ not reported · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in patient satisfaction with abortion care overall compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

1 finding from 1 review