FEV1 L and % predicted Absolute change from baseline · adults and children with cystic fibrosis and with at least one G551D CFTR mutation
1 finding from 1 review
Adverse events · adults and children with cystic fibrosis and with at least one G551D CFTR mutation
1 finding from 1 review
Time to first pulmonary exacerbation · adults and children with cystic fibrosis and with at least one G551D CFTR mutation
Summary of findings ‐ ivacaftor probably leads to lower time to first pulmonary exacerbation compared with placebo (moderate certainty).
1 finding from 1 review
Survival · adults and children with cystic fibrosis and with at least one R117H CFTR mutation
1 finding from 1 review
QoL · adults and children with cystic fibrosis and with at least one R117H CFTR mutation
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
QoL (CFQ‐R) Respiratory domain · adults and children with cystic fibrosis and with at least one R117H CFTR mutation
1 finding from 1 review
FEV1 % predicted: relative change from baseline · adults and children with cystic fibrosis and with at least one R117H CFTR mutation
1 finding from 1 review
FEV1 L and % predicted Absolute change from baseline · adults and children with cystic fibrosis and with at least one R117H CFTR mutation
1 finding from 1 review
QoL · adults and children with cystic fibrosis and with the F508del CFTR mutation
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · adults and children with cystic fibrosis and with at least one R117H CFTR mutation
1 finding from 1 review
Time to first pulmonary exacerbation · adults and children with cystic fibrosis and with at least one R117H CFTR mutation
Summary of findings ‐ ivacaftor showed no clear difference in time to first pulmonary exacerbation compared with placebo (moderate certainty).
1 finding from 1 review
QoL (CFQ‐R) Respiratory domain · adults and children with cystic fibrosis and with the F508del CFTR mutation
1 finding from 1 review
FEV1 % predicted: relative change from baseline · adults and children with cystic fibrosis and with the F508del CFTR mutation
1 finding from 1 review
FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis and with the F508del CFTR mutation
1 finding from 1 review
Adverse events · adults and children with cystic fibrosis and with the F508del CFTR mutation
1 finding from 1 review
Time to first pulmonary exacerbation · adults and children with cystic fibrosis and with the F508del CFTR mutation
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Survival · adults and children with cystic fibrosis and with at least one G551D CFTR mutation
1 finding from 1 review
QoL · adults and children with cystic fibrosis and with at least one G551D CFTR mutation
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Postoperative delirium (POD) within 7 days (As assessed by any method such as the Mini‐Mental State Examination (MMSE) and Confusion Assessment Method (CAM) in the first week after operation) · adults aged 18 years or over undergoing general anaesthesia for non‐cardiac or non‐neurosurgical elective operations
The intervention probably leads to lower postoperative delirium (POD) within 7 days (As assessed by any… (moderate certainty).
1 finding from 1 review
Intervention not reported
Postoperative cognitive dysfunction (POCD) (As determined by any method of assessing POCD including a battery of neuropsychological tests according to the criteria described by the International Study of Postoperative Cognitive Dysfunction (ISPOCD)) · adults aged 18 years or over undergoing general anaesthesia for non‐cardiac or non‐neurosurgical elective operations
The intervention showed no clear difference in postoperative cognitive dysfunction (POCD) (As determined by any… (moderate certainty).
1 finding from 1 review