Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

353 questions · 366 findings · 17 reviews · Oral and maxillofacial surgery

No studies found 86 · 23.5%GRADE not reported 233 · 63.7%Very low 42 · 11.5%Low 3 · 0.8%Moderate 2 · 0.5%High 0 · 0%

Glucosamine sulfate (oral) vs ibuprofen

Pain during function (proportion without significant improvement) · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Glucosamine sulfate (oral) led to lower pain during function (proportion without significant improvement) compared with ibuprofen (oral); GRADE not reported.

1 finding from 1 review
  • Six participants in the glucosamine group did not experience significant improvement in TMJ pain compared with seven in the ibuprofen group (Analysis 3.1); Fisher's exact test P = 0.73 (not significant, per the authors).
    1 study · 45 participants
    GRADE not reported

Breastfeeding (post cleft-lip surgery) vs Spoon-feeding

Weight (kg) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…

Breastfeeding (post cleft-lip surgery) led to higher weight (kg) compared with spoon-feeding; GRADE not reported.

1 finding from 1 review

Maternal advice and support (feeding techniques/breastfeeding positions) vs Usual care (no additional advice/support)

Outcome not reported · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…

The review found no eligible studies for this question.

1 finding from 1 review

Breastfeeding (post cleft-lip surgery) vs Spoon-feeding

Length of hospital stay · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…
1 finding from 1 review

Squeezable (modified) feeding bottle vs Rigid feeding bottle

Energy and protein intake · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…
1 finding from 1 review

Passive maxillary/obturating plate (worn until surgical closure of soft palate) vs No plate

Weight (kg) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…

Passive maxillary/obturating plate (worn until surgical closure of… showed no clear difference in weight (kg) compared with no plate; GRADE not reported.

1 finding from 1 review

Squeezable (modified) feeding bottle vs Rigid feeding bottle

Weight (kg) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…

Squeezable (modified) feeding bottle showed no clear difference in weight (kg) compared with rigid feeding bottle; GRADE not reported.

1 finding from 1 review

Squeezable (modified) feeding bottle vs Rigid feeding bottle

Reliability of feeding method (number of times bottle modified) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…
1 finding from 1 review

Breastfeeding (post cleft-lip surgery) vs Spoon-feeding

Adverse events (wound dehiscence; lip scar hypertrophy) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…
1 finding from 1 review

Passive maxillary/obturating plate (worn until surgical closure of soft palate) vs No plate

Head circumference (mm) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…

Passive maxillary/obturating plate (worn until surgical closure of… showed no clear difference in head circumference (cm) compared with no plate; GRADE not reported.

1 finding from 1 review

Squeezable (modified) feeding bottle vs Rigid feeding bottle

Length (cm) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…

Squeezable (modified) feeding bottle showed no clear difference in length (cm) compared with rigid feeding bottle; GRADE not reported.

1 finding from 1 review

Breastfeeding (post cleft-lip surgery) vs Spoon-feeding

Cost of hospitalisation · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…
1 finding from 1 review

Passive maxillary/obturating plate (worn until surgical closure of soft palate) vs No plate

Length (cm) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…

Passive maxillary/obturating plate (worn until surgical closure of… showed no clear difference in length (cm) compared with no plate; GRADE not reported.

1 finding from 1 review

Squeezable (modified) feeding bottle vs Rigid feeding bottle

Quality of life and parental satisfaction (crying, feeding, sleeping, playing time; 24-hour parental log) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…
1 finding from 1 review

Squeezable (modified) feeding bottle vs Rigid feeding bottle

Head circumference (mm) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…

Squeezable (modified) feeding bottle led to lower head circumference (cm) compared with rigid feeding bottle; GRADE not reported.

1 finding from 1 review

Immediate-delayed implants (placed within 8 weeks after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Major complications at the implant site · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate-delayed implants (placed within 8 weeks after tooth… led to higher major complications at the implant site compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.

1 finding from 1 review

Oral glucosamine hydrochloride/chondroitin sulphate vs placebo

Pain on TMJ palpation (ordinal scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral glucosamine hydrochloride/chondroitin sulphate showed no clear difference in pain on TMJ palpation (ordinal scale) compared with placebo; GRADE not reported.

1 finding from 1 review

Summary of findings table ‐ Topical capsaicin vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Oral gabapentin vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Bio-Oss (anorganic bovine bone) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Bone gain (horizontal - HDD) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Bio-Oss (anorganic bovine bone) showed no clear difference in bone gain (horizontal - HDD) compared with bio-Oss + resorbable barrier; GRADE not reported.

1 finding from 1 review