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What do systematic reviews say?

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Evidence found and GRADE certainty

660 questions · 679 findings · 99 reviews · Headline outcomes only

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No studies found 160 · 23.6%GRADE not reported 17 · 2.5%Very low 199 · 29.3%Low 189 · 27.8%Moderate 97 · 14.3%High 17 · 2.5%

Intrauterine infusion/injection of autologous platelet‐rich plasma vs placebo or no intervention

Adverse event ‐ multiple pregnancy · women undergoing assisted reproduction

It is very uncertain whether intrauterine infusion/injection of autologous platelet‐rich plasma changes adverse events: multiple pregnancy compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Intrauterine infusion/injection of autologous platelet‐rich plasma vs placebo or no intervention

Adverse events: ectopic pregnancy · women undergoing assisted reproduction

It is very uncertain whether intrauterine infusion/injection of autologous platelet‐rich plasma changes adverse events: ectopic pregnancy compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Live zoster vaccine vs placebo

Participants with adverse events ‐ injection site adverse events Clinical criteria · healthy older adults aged ≥ 60 years

Live zoster vaccine probably leads to higher participants with adverse events ‐ injection site adverse… compared with placebo (moderate certainty).

1 finding from 1 review

Low molecular weight heparin vs no prophylaxis

All adverse effects, including allergies at injection site, minor and major bleeding, others ( · adults undergoing KA

Low‐molecular‐weight heparin showed no clear difference in all adverse effects, including allergies at injection site, minor… compared with no prophylaxis (moderate certainty).

1 finding from 1 review

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

Vertigo/dizziness: at the time of injection · sudden sensorineural hearing loss
2 findings from 1 review

Intratympanic plus systemic corticosteroids (combined therapy) vs systemic corticosteroids alone

Ear pain: at the time of injection · sudden sensorineural hearing loss
2 findings from 1 review

Laser therapy vs other treatments

Incidence and severity of treatment‐related adverse effects ‐ fractional carbon dioxide (CO2) laser versus TAC ‐ pain at injection site ‐ keloid scars ‐ · participants with hypertrophic and keloid scars

It is very uncertain whether laser therapy changes incidence and severity of treatment‐related adverse effects ‐… compared with other treatments (very low certainty).

1 finding from 1 review

Laser therapy vs other treatments

Incidence and severity of treatment‐related adverse effects ‐ fractional CO2 laser versus verapamil ‐ pain at injection site ‐ keloid scars ‐ · participants with hypertrophic and keloid scars

It is very uncertain whether laser therapy changes incidence and severity of treatment‐related adverse effects ‐… compared with other treatments (very low certainty).

1 finding from 1 review

Insulin glargine vs NPH insulin

Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring 00:01‐05:59 (Davies 2014) or 23:00‐07:00 (BEGIN Young)

Summary of findings: insulin glargine showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with NPH insulin (moderate certainty).

1 finding from 1 review

Intervention not reported

Cost of analgesic regimens for single‐injection blocks · patients with hip fracture
1 finding from 1 review