Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

254 questions · 269 findings · 31 reviews

No studies found 34 · 12.6%GRADE not reported 3 · 1.1%Very low 70 · 26%Low 93 · 34.6%Moderate 44 · 16.4%High 25 · 9.3%

PUFA vs placebo

50% reduction in seizures frequency (12 weeks) ‐ Per protocol data ‐ Older (19 years or more) · patients with drug‐resistant epilepsy

PUFA showed no clear difference in 50% reduction in seizures frequency (12 weeks) ‐ Per protocol data ‐… compared with placebo (low certainty).

1 finding from 1 review

PUFA vs placebo

50% reduction in seizures frequency (12 weeks) ‐ Per protocol data ‐ Younger (< 19 years) · patients with drug‐resistant epilepsy

PUFA may leads to higher 50% reduction in seizures frequency (12 weeks) ‐ Per protocol data ‐… compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Relapse rate at one year (all studies) · Crohn's disease patients in remission

It is very uncertain whether the intervention changes relapse rate at one year (all studies) (very low certainty).

1 finding from 1 review

Intervention not reported

Relapse rate at one year (sensitivity analysis of Belluzi 1996) · Crohn's disease patients in remission

It is very uncertain whether the intervention changes relapse rate at one year (sensitivity analysis of Belluzi 1996) (very low certainty).

1 finding from 1 review

Intervention not reported

Relapse rate at one year (only EPIC studies) · Crohn's disease patients in remission

The intervention showed no clear difference in relapse rate at one year (only EPIC studies) (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events rate‐ Upper GI (nausea, vomiting, halitosis, heartburn, dyspepsia, dysgeusia and bloating) · Crohn's disease patients in remission

The intervention probably leads to higher adverse events rate‐ Upper GI (nausea, vomiting, halitosis,… (moderate certainty).

1 finding from 1 review