Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,005 questions · 1,053 findings · 151 reviews · Headline outcomes only

No studies found 275 · 26.1%GRADE not reported 150 · 14.2%Very low 271 · 25.7%Low 215 · 20.4%Moderate 105 · 10%High 37 · 3.5%

Lamotrigine vs lithium

Any reported adverse effects 6‐12 months after initiating the intervention (long term) · bipolar disorder

Lamotrigine probably leads to lower any reported adverse effects 6‐12 months after initiating the… compared with lithium (moderate certainty).

1 finding from 1 review

Lamotrigine vs placebo

Withdrawal from treatment due to any reason, 6‐12 months after intervention initiation (long term) · bipolar disorder

Lamotrigine probably leads to lower withdrawal from treatment due to any reason, 6‐12 months after… compared with placebo (moderate certainty).

1 finding from 1 review

Lamotrigine vs placebo

Any reported adverse effects 6‐12 months after initiating the intervention (long term) · bipolar disorder

Lamotrigine showed no clear difference in any reported adverse effects 6‐12 months after initiating the… compared with placebo (moderate certainty).

1 finding from 1 review

tDCS vs active control

Secondary outcome measure: lower extremity function at the end of · people with stroke
2 findings from 1 review

tDCS vs active control

Muscle strength · people with stroke
2 findings from 1 review

tDCS vs active control

Secondary outcome measure: cognitive abilities at the end of · people with stroke

The review found no eligible studies for this question.

2 findings from 1 review

tDCS vs active control

Dropouts, adverse events and deaths during intervention phase Numbers of dropouts, adverse events and deaths from all causes · people with stroke

tDCS showed no clear difference in secondary outcome measure: dropouts, adverse events and deaths… compared with any type of active control intervention (moderate certainty).

1 finding from 1 review

tDCS vs active control

ADL outcome · people with stroke

The review found no eligible studies for this question.

2 findings from 1 review

tDCS vs active control

Secondary outcome measure: mean upper extremity function at the end of the intervention periodClinical measures of upper extremity function. Scale from: 0 to infinity. · people with stroke
2 findings from 1 review

tDCS vs placebo or control

Dropouts, adverse events and deaths during intervention phase Numbers of dropouts, adverse events and deaths from all causes · people with stroke

tDCS showed no clear difference in secondary outcome measure: dropouts, adverse events and deaths… compared with any type of placebo or passive control intervention (moderate certainty).

1 finding from 1 review

Self‐administered medical abortion vs provider‐administered medical abortion

Any complication requiring surgical intervention ‐ NRSs ( · women of reproductive age (15 to 49 years) seeking induced abortion

The review found no eligible studies for this question.

2 findings from 1 review