Findings

What do systematic reviews say?

4,760 questions · 8,065 findings · 1,036 reviews

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No studies found 1,686 · 20.9%GRADE not reported 675 · 8.4%Very low 1,953 · 24.2%Low 2,048 · 25.4%Moderate 1,296 · 16.1%High 407 · 5%

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Prevention of eclampsia: higher vs lower IV maintenance regimen

Eclampsia: 2 g per hour IV versus weight‐adjusted maintenance dose · women with pre‐eclampsia

1 finding from 1 review

Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 86 participants
Very low

Prevention of eclampsia: higher vs lower IV maintenance regimen

Severe morbidity · women with pre‐eclampsia

The review found no eligible studies for this question.

1 finding from 1 review

Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Prevention of eclampsia: higher vs lower IV maintenance regimen

Side effects · women with pre‐eclampsia

Prevention of eclampsia: higher showed no clear difference in side effects compared with lower IV maintenance regimen (low certainty).

1 finding from 1 review

Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
RR 0.79 [0.61, 1.01]
1 study · 62 participants
Low

Prevention of eclampsia: higher vs lower IV maintenance regimen

Death of baby (up to discharge) · women with pre‐eclampsia

The review found no eligible studies for this question.

1 finding from 1 review

Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Prevention of eclampsia: higher vs lower IV maintenance regimen

Maternal death · women with pre‐eclampsia

The review found no eligible studies for this question.

1 finding from 1 review

Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Prevention of eclampsia: higher vs lower IV maintenance regimen

Other neonatal morbidity · women with pre‐eclampsia

The review found no eligible studies for this question.

1 finding from 1 review

Alternative magnesium sulphate regimens for women with pre‐eclampsia and eclampsia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Rabeprazole at higher doses (1 mg/kg) vs rabeprazole at lower doses (0.5 mg/kg)

Improvement in symptoms · GORD in children over 1 year of age

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 127 participants
Very low

Rabeprazole at higher doses (1 mg/kg) vs rabeprazole at lower doses (0.5 mg/kg)

Adverse events · GORD in children over 1 year of age

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 127 participants
Very low

Rabeprazole at higher doses (1 mg/kg) vs rabeprazole at lower doses (0.5 mg/kg)

Endoscopic improvement (dichotomous) · GORD in children over 1 year of age

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 127 participants
Very low

Rabeprazole at higher doses (1 mg/kg) vs rabeprazole at lower doses (0.5 mg/kg)

pH indices ‐ not measured · GORD in children over 1 year of age

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pantoprazole in higher doses (1.2 mg/kg) vs pantoprazole at lower doses (0.3 mg/kg)

Improvement in symptoms · GORD in children over 1 year of age

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Pantoprazole in higher doses (1.2 mg/kg) vs pantoprazole at lower doses (0.3 mg/kg)

Adverse events · GORD in children over 1 year of age

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Pantoprazole in higher doses (1.2 mg/kg) vs pantoprazole at lower doses (0.3 mg/kg)

Improvement in pH indices ‐ not measured · GORD in children over 1 year of age

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pantoprazole in higher doses (1.2 mg/kg) vs pantoprazole at lower doses (0.3 mg/kg)

Endoscopic metrics ‐ not measured · GORD in children over 1 year of age

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment of gastro‐oesophageal reflux in children 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Zinc vs placebo

BMD Z score (total hip/femoral neck) · children and adults with β‐thalassaemia major and low bone mass

Summary of findings – zinc probably leads to higher BMD Z score (total hip/femoral neck) compared with placebo (moderate certainty).

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
MD 0.15 [0.11, 0.19]
1 study · 37 participants
Moderate

Zinc vs placebo

BMD Z score (lumbar spine) · children and adults with β‐thalassaemia major and low bone mass

Summary of findings – zinc probably leads to higher BMD Z score (lumbar spine) compared with placebo (moderate certainty).

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
MD 0.15 [0.1, 0.2]
1 study · 37 participants
Moderate

Zinc vs placebo

BMD Z score (wrist) · children and adults with β‐thalassaemia major and low bone mass

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Zinc vs placebo

Incidence of fractures · children and adults with β‐thalassaemia major and low bone mass

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Zinc vs placebo

Mobility · children and adults with β‐thalassaemia major and low bone mass

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Zinc vs placebo

Quality of life · children and adults with β‐thalassaemia major and low bone mass

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found