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Evidence found and GRADE certainty

2,922 questions · 3,118 findings · 513 reviews

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No studies found 574 · 18.4%GRADE not reported 372 · 11.9%Very low 723 · 23.2%Low 854 · 27.4%Moderate 489 · 15.7%High 106 · 3.4%

Higher vs lower FiO2 or targets of arterial oxygenation

Myocardial infarction · adults admitted to the ICU

It is very uncertain whether higher changes myocardial infarction diagnosed after randomisation: range ≤ 90 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Stroke · adults admitted to the ICU

It is very uncertain whether higher changes stroke diagnosed after randomisation: range 1 mo to 3 mo compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Sepsis diagnosed after randomisation: range 28 d to 60 d · adults admitted to the ICU

It is very uncertain whether higher changes sepsis diagnosed after randomisation: range 28 d to 60 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

Incidence of severe hypoxaemia (SpO2 < 80%) · people requiring tracheal intubation

Oxygenation showed no clear difference in incidence of severe hypoxaemia (SpO2 < 80%) compared with no oxygenation during the apnoeic period preceding intubation (low certainty).

1 finding from 1 review

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

Hypoxaemia · people requiring tracheal intubation

Oxygenation showed no clear difference in incidence of hypoxaemia (SpO2 < 93%) compared with no oxygenation during the apnoeic period preceding intubation (low certainty).

1 finding from 1 review

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

First‐pass success of cannulation · people requiring tracheal intubation

Oxygenation showed no clear difference in first pass success rate compared with no oxygenation during the apnoeic period preceding intubation (moderate certainty).

1 finding from 1 review

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

All‐cause mortality · people requiring tracheal intubation

Oxygenation showed no clear difference in mortality compared with no oxygenation during the apnoeic period preceding intubation (low certainty).

1 finding from 1 review

Laser trabeculoplasty vs medication

Failure to stabilise visual field progression (as defined by study investigators) · people with open‐angle glaucoma

Laser trabeculoplasty showed no clear difference in failure to stabilise visual field progression (as defined by study… compared with medication (moderate certainty).

1 finding from 1 review

Laser trabeculoplasty vs medication

Failure to stabilise optic neuropathy progression (as defined by study investigators) · people with open‐angle glaucoma

It is very uncertain whether laser trabeculoplasty changes failure to stabilise optic neuropathy progression (as defined by… compared with medication (very low certainty).

1 finding from 1 review