Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,345 questions · 4,525 findings · 483 reviews

No studies found 1,024 · 22.6%GRADE not reported 388 · 8.6%Very low 1,172 · 25.9%Low 1,227 · 27.1%Moderate 576 · 12.7%High 138 · 3%

Interferon + chemotherapy vs chemotherapy alone

Adverse event (flu‐like symptoms) · Women with advanced (Stage II‐IV) epithelial ovarian cancer who have undergone surgery

Interferon + chemotherapy showed no clear difference in adverse event (flu‐like symptoms) compared with chemotherapy alone (low certainty).

1 finding from 1 review

Perioperative statins vs placebo or no treatment

All cardiovascular death · participants with improving outcomes during and after noncardiac vascular surgery.

Perioperative statins showed no clear difference in death from cardiovascular causes compared with placebo or no treatment (low certainty).

1 finding from 1 review

Perioperative statins vs placebo or no treatment

Non‐fatal MI · participants with improving outcomes during and after noncardiac vascular surgery.

Perioperative statins showed no clear difference in myocardial infarction (non‐fatal) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Intervention not reported

Surgical failure (intraocular pressure >21mmHg) ( · patients with glaucoma surgery

The intervention probably leads to lower surgical failure (intraocular pressure >21mmHg) ( (moderate certainty).

1 finding from 1 review

Intervention not reported

Intraocular pressure ( · patients with glaucoma surgery
1 finding from 1 review

Intervention not reported

Adverse effect: cataract · patients with glaucoma surgery

The intervention showed no clear difference in adverse effect: cataract (moderate certainty).

1 finding from 1 review

Intervention not reported

Overall five year survival ‐ Colorectal cancer · Patients with outcomes after colorectal cancer surgery

It is very uncertain whether the intervention changes overall five year survival ‐ Colorectal cancer (very low certainty).

1 finding from 1 review

Intervention not reported

Permanent stoma rate ‐ Rectal cancer · Patients with outcomes after colorectal cancer surgery

It is very uncertain whether the intervention changes permanent stoma rate ‐ Rectal cancer (very low certainty).

1 finding from 1 review

Intervention not reported

Abdominoperineal excision of the rectum rate ‐ Rectal cancer · Patients with outcomes after colorectal cancer surgery

It is very uncertain whether the intervention changes abdominoperineal excision of the rectum rate ‐ Rectal cancer (very low certainty).

1 finding from 1 review

Intervention not reported

Overall five year survival ‐ Colorectal cancer · Patients with outcomes after colorectal cancer surgery

The intervention may leads to lower overall five year survival ‐ Colorectal cancer (low certainty).

1 finding from 1 review