Cochrane · systematic review · CD009971

Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery

Sanders, RD, Nicholson, A, Lewis, SR, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library

AnaesthesiaAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 1 · 16.7%Ungraded 1 · 16.7%Very low 0 · 0%Low 3 · 50%Moderate 1 · 16.7%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Perioperative statins versus placebo or no treatment for improving outcomes during and after noncardiac vascular surgery

Population: participants with improving outcomes during and after noncardiac vascular surgery.

6 questions

Outcome	Effect	Evidence	Status / GRADE
All‐cause mortality Perioperative statins vs placebo or no treatment	RR 0.73 [0.31, 1.75]	3 studies · 178 participants	Low Downgraded: imprecision
Death from cardiovascular causes Perioperative statins vs placebo or no treatment	RR 1.05 [0.07, 16.2]	3 studies · 178 participants	Low Downgraded: imprecision
Myocardial infarction (non‐fatal) Perioperative statins vs placebo or no treatment	RR 0.47 [0.15, 1.52]	3 studies · 178 participants	Moderate Downgraded: imprecision
Stroke/TIA (non‐fatal) Perioperative statins vs placebo or no treatment	RR 0.24 [0.03, 2.25]	3 studies · 178 participants	Low Downgraded: imprecision
Participant‐reported outcomes－not measured Perioperative statins vs placebo or no treatment	no estimate extracted	NR	No studies
Adverse muscle effects Perioperative statins vs placebo or no treatment	no estimate extracted	3 studies · 188 participants	Ungraded