Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,736 questions · 15,265 findings · 1,163 reviews · Headline outcomes only

No studies found 3,871 · 25.4%GRADE not reported 810 · 5.3%Very low 4,242 · 27.8%Low 3,879 · 25.4%Moderate 1,999 · 13.1%High 464 · 3%

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Facilitated tucking / four‐handed care / gentle human touch vs usual care

Heart rate · neonates with mechanical ventilation

Facilitated tucking / four‐handed care / gentle human touch showed no clear difference in heart rate compared with standard care (low certainty).

1 finding from 1 review

Facilitated tucking / four‐handed care / gentle human touch vs usual care

SaO 2 during endotracheal suctioning · neonates with mechanical ventilation

Facilitated tucking / four‐handed care / gentle human touch showed no clear difference in saO 2 during endotracheal suctioning compared with standard care (low certainty).

1 finding from 1 review

Facilitated tucking / four‐handed care / gentle human touch vs usual care

SDB during endotracheal suctioning · neonates with mechanical ventilation

Facilitated tucking / four‐handed care / gentle human touch showed no clear difference in SDB during endotracheal suctioning compared with standard care (low certainty).

1 finding from 1 review

Facilitated tucking / four‐handed care / gentle human touch vs usual care

SRB during endotracheal suctioning · neonates with mechanical ventilation

Facilitated tucking / four‐handed care / gentle human touch may leads to higher SRB during endotracheal suctioning compared with standard care (low certainty).

1 finding from 1 review

Doxepin cream vs oral antihistamine

Change in burn‐related pruritus (VAS) ( · people with postburn pruritus

Doxepin cream showed no clear difference in change in burn‐related pruritus (VAS) ( compared with oral antihistamine (low certainty).

1 finding from 1 review

Ondansetron vs diphenhydramine

Change in burn‐related pruritus (VAS) ( · people with postburn pruritus

Ondansetron showed no clear difference in change in burn‐related pruritus (NAS) ( compared with diphenhydramine (antihistamine) (moderate certainty).

1 finding from 1 review

Enalapril ointment vs placebo

Change in burn‐related pruritus (VAS) ( · people with postburn pruritus

Enalapril ointment showed no clear difference in change in burn‐related pruritus (Scoring table for itching) ( compared with placebo (moderate certainty).

1 finding from 1 review

Massage vs usual care

Change in burn‐related pruritus (VAS) ( · people with postburn pruritus

Massage therapy showed no clear difference in change in burn‐related pruritus Itching scale ( compared with standard care (low certainty).

1 finding from 1 review