Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,556 questions · 2,794 findings · 119 reviews · All outcomes

No studies found 489 · 17.5%GRADE not reported 1,719 · 61.5%Very low 399 · 14.3%Low 128 · 4.6%Moderate 58 · 2.1%High 1 · 0%

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Prosthetic failure (2 years) · Patients with atrophic (resorbed) mandibles needing implants

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… showed no clear difference in prosthetic failure compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

1 finding from 1 review

Enzyme cleanser vs Placebo / sham solution

Improvement on denture cleanliness (caregivers' opinion) · Institutionalised elderly wearing maxillary complete dentures (CD)

Enzyme cleanser led to lower improvement on denture cleanliness (caregivers' opinion) compared with placebo / sham solution; GRADE not reported.

1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    12 weeks
    After 12 weeks using an enzyme denture cleanser ('E'), 8 of 18 caregivers perceived some improvement in CD cleanliness. After using a placebo solution ('Plac'), only 2 of 17 perceived some improvement (Analysis 1.1,…
    1 study · 35 participants
    GRADE not reported

Ultrasound during vertical distraction osteogenesis vs Placebo (no ultrasound) during vertical distraction

Distraction distance (bone gain, mm) · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Ultrasound during vertical distraction osteogenesis showed no clear difference in distraction distance (bone gain, mm) compared with placebo (no ultrasound) during vertical distraction; GRADE not reported.

1 finding from 1 review

Effervescent tablets vs Association of brushing and effervescent tablets

Total anaerobes (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Effervescent tablets showed no clear difference in total anaerobes (colony forming units, log-transformed) compared with association of brushing and effervescent tablets; GRADE not reported.

1 finding from 1 review

Prophylactic aciclovir (oral or intravenous) vs placebo

Length of hospital stay · Patients being treated for cancer (predominantly haematological malignancies)

The review found no eligible studies for this question.

1 finding from 1 review

Vertical distraction osteogenesis vs Autogenous inlay bone graft (iliac crest)

Vertical bone gain · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical distraction osteogenesis led to higher vertical bone gain compared with autogenous inlay bone graft (iliac crest); GRADE not reported.

1 finding from 1 review

Vertical GBR with non-resorbable titanium-reinforced barriers vs Vertical GBR with resorbable barriers supported by osteosynthesis plates

Augmentation procedure failure · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical GBR with non-resorbable titanium-reinforced barriers showed no clear difference in augmentation procedure failure compared with vertical GBR with resorbable barriers supported by osteosynthesis…; GRADE not reported.

1 finding from 1 review

Enzyme cleanser vs Placebo / sham solution

Denture plaque · Institutionalised elderly wearing maxillary complete dentures (CD)
1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    5 weeks; 3 months
    Both interventions reduced biofilm scores after 2 weeks. However, plaque scores were significantly lower for 'E' after 5 weeks (P < 0.05) and 3 months (P < 0.01), as assessed by Chi2 test. It was not possible to…
    1 study
    GRADE not reported

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Major complications · Patients with atrophic (resorbed) mandibles needing implants

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… led to higher major complications compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

1 finding from 1 review

1-stage (non-submerged) implant placement vs 2-stage (submerged) implant placement

Patient preference including aesthetics (split-mouth studies only) · People with dental implants

The review found no eligible studies for this question.

1 finding from 1 review

Vertical GBR with non-resorbable titanium-reinforced barriers vs Vertical GBR with resorbable barriers supported by osteosynthesis plates

Perimplant bone loss · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical GBR with non-resorbable titanium-reinforced barriers showed no clear difference in perimplant bone loss (3 years) compared with vertical GBR with resorbable barriers supported by osteosynthesis…; GRADE not reported.

1 finding from 1 review

Inlay autogenous bone graft (iliac crest) vs Autogenous onlay bone graft (iliac crest)

Major complications · Patients with deficient posterior mandibles (4.5 to 10 mm above the mandibular canal) needing implants

Autogenous inlay bone graft (iliac crest) showed no clear difference in major complications compared with autogenous onlay bone graft (iliac crest); GRADE not reported.

1 finding from 1 review

Vertical GBR with non-resorbable titanium-reinforced barriers vs Vertical GBR with resorbable barriers supported by osteosynthesis plates

Vertical bone gain · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical GBR with non-resorbable titanium-reinforced barriers showed no clear difference in vertical bone gain compared with vertical GBR with resorbable barriers supported by osteosynthesis…; GRADE not reported.

1 finding from 1 review

Inlay autogenous bone graft (iliac crest) vs Autogenous onlay bone graft (iliac crest)

Vertical bone gain · Patients with deficient posterior mandibles (4.5 to 10 mm above the mandibular canal) needing implants

Autogenous inlay bone graft (iliac crest) showed no clear difference in vertical bone gain compared with autogenous onlay bone graft (iliac crest); GRADE not reported.

1 finding from 1 review

1-stage (non-submerged) implant placement vs 2-stage (submerged) implant placement

Marginal bone level change · People with dental implants

1-stage (non-submerged) implant placement showed no clear difference in radiographic marginal bone level changes compared with 2-stage (submerged) implant placement; GRADE not reported.

1 finding from 1 review

1-stage (non-submerged) implant placement vs 2-stage (submerged) implant placement

Implant failure · People with dental implants

1-stage (non-submerged) implant placement showed no clear difference in implant failure compared with 2-stage (submerged) implant placement (moderate certainty).

1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Patient quality of life · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)

The review found no eligible studies for this question.

1 finding from 1 review

Brushing vs No treatment (immersion in distilled water)

Microbial counts (total aerobes, anaerobes, yeasts) · Complete denture (CD) wearers in a nursing home
1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    Moore 1984 found that the seven tested methods were similar and resulted in a significant reduction in total aerobes and anaerobes compared with immersion in distilled water (paired t test, P < 0.05). Some chemical…
    1 study · 12 participants
    GRADE not reported

Vertical distraction osteogenesis vs Autogenous inlay bone graft (iliac crest)

Complications · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical distraction osteogenesis showed no clear difference in complications compared with autogenous inlay bone graft (iliac crest); GRADE not reported.

1 finding from 1 review

Prophylactic aciclovir (oral or intravenous) vs placebo

Recurrence of lesions · Patients being treated for cancer (predominantly haematological malignancies)

The review found no eligible studies for this question.

1 finding from 1 review