Findings

What do systematic reviews say?

3,018 questions · 3,100 findings · 369 reviews · Headline outcomes only

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No studies found 774 · 25%GRADE not reported 108 · 3.5%Very low 727 · 23.5%Low 840 · 27.1%Moderate 474 · 15.3%High 177 · 5.7%

NSAIDs vs placebo

Delayed antibiotic prescriptions

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs paracetamol

hours

It is very uncertain whether NSAIDs changes hours compared with paracetamol (very low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 0.83 [0.59, 1.18]
2 studies · 39 participants
Very low

NSAIDs vs paracetamol

to 72 hours

NSAIDs showed no clear difference in to 72 hours compared with paracetamol (low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 0.91 [0.54, 1.54]
3 studies · 183 participants
Low

NSAIDs vs paracetamol

to 7 days

It is very uncertain whether NSAIDs changes to 7 days compared with paracetamol (very low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 0.74 [0.17, 3.23]
2 studies · 38 participants
Very low

Paracetamol vs placebo

to 72 hours (48 hours)

Paracetamol may leads to lower to 72 hours (48 hours) compared with placebo (low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 0.38 [0.17, 0.85]
1 study · 148 participants
Low

NSAIDs vs paracetamol

Adverse events

It is very uncertain whether NSAIDs changes adverse events compared with paracetamol (very low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 1.71 [0.43, 6.9]
3 studies · 281 participants
Very low

NSAIDs vs paracetamol

Mean time to resolution of pain

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs paracetamol

Reconsultations

It is very uncertain whether NSAIDs changes reconsultations compared with paracetamol (very low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 1.13 [0.92, 1.4]
1 study · 53 participants
Very low

NSAIDs vs paracetamol

Delayed antibiotic prescriptions

It is very uncertain whether NSAIDs changes delayed antibiotic prescriptions compared with paracetamol (very low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 1.32 [0.74, 2.35]
1 study · 53 participants
Very low

Paracetamol vs placebo

to 7 days

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Paracetamol vs placebo

Adverse events

It is very uncertain whether paracetamol changes adverse events compared with placebo (very low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 1.03 [0.21, 4.93]
1 study · 148 participants
Very low

Paracetamol vs placebo

Mean time to resolution of pain

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Paracetamol vs placebo

Mean pain score at various time points

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Paracetamol vs placebo

Reconsultations

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Paracetamol vs placebo

Delayed antibiotic prescriptions

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

hours

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Progression of DRa · people with type 2 diabetes

The intervention showed no clear difference in progression of DRa (moderate certainty).

1 finding from 1 review

Fenofibrate for diabetic retinopathy 2023 · Cochrane Headline outcomes only
RR 0.86 [0.6, 1.25]
1 study · 1012 participants
Moderate

Intervention not reported

Incidence of a reduction in visual acuity of 10 ETDR letters or more · people with type 2 diabetes

The review found no eligible studies for this question.

1 finding from 1 review

Fenofibrate for diabetic retinopathy 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Incidence of PDR · people with type 2 diabetes

The review found no eligible studies for this question.

1 finding from 1 review

Fenofibrate for diabetic retinopathy 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Incidence of DMOa · people with type 2 diabetes

The intervention showed no clear difference in incidence of DMOa (moderate certainty).

1 finding from 1 review

Fenofibrate for diabetic retinopathy 2023 · Cochrane Headline outcomes only
RR 0.39 [0.12, 1.24]
1 study · 850 participants
Moderate