Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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Varenicline vs e‐cigarettes

Smoking abstinence at longest · people who continued to smoke tobacco following acute coronary syndrome

It is very uncertain whether varenicline changes smoking abstinence at longest compared with e‐cigarettes (very low certainty).

1 finding from 1 review

High vs low dose pegylated interferon alpha‐2a or alpha‐2b

PEG interferon alpha‐2a · patients on HD with HCV infection

High showed no clear difference in PEG interferon alpha‐2a compared with low dose pegylated interferon alpha‐2a or alpha‐2b (low certainty).

4 findings from 1 review
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High vs low dose pegylated interferon alpha‐2a or alpha‐2b

PEG interferon (alpha‐2b) · patients on HD with HCV infection

High showed no clear difference in PEG interferon alpha‐2b compared with low dose pegylated interferon alpha‐2a or alpha‐2b (low certainty).

2 findings from 1 review

High vs low dose pegylated interferon alpha‐2a or alpha‐2b

PEG interferon (combined) · patients on HD with HCV infection

High showed no clear difference in PEG interferon (combined) compared with low dose pegylated interferon alpha‐2a or alpha‐2b (moderate certainty).

3 findings from 1 review