What do systematic reviews say?

Calcitonin (salmon calcitonin nasal spray 200 IU/day) vs placebo

• Interventions for central giant cell granuloma (CGCG) of the jaws 2009 · Cochrane All outcomes
  Adverse events were not described separately for each group. Trialists reported that adverse events were in most patients minimal and consisted of nausea, flushes and some dizziness. One patient had diarrhoea which…
  1 study · 14 participants
  GRADE not reported

Aciclovir (oral or intravenous) for treatment vs placebo

The review found no eligible studies for this question.

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  For the treatment comparison (aciclovir versus placebo), no data were available for recurrence of lesions, amount of analgesia, days of stay in hospital, cost of oral care or patient quality of life.
  0 studies
  No studies found

Aciclovir (oral or intravenous) for treatment vs placebo

The review found no eligible studies for this question.

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  For the treatment comparison (aciclovir versus placebo), no data were available for recurrence of lesions, amount of analgesia, days of stay in hospital, cost of oral care or patient quality of life.
  0 studies
  No studies found

Aciclovir (oral or intravenous) for treatment vs placebo

The review found no eligible studies for this question.

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  For the treatment comparison (aciclovir versus placebo), no data were available for recurrence of lesions, amount of analgesia, days of stay in hospital, cost of oral care or patient quality of life.
  0 studies
  No studies found

Aciclovir (oral or intravenous) for treatment vs placebo

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  Adverse effects were assessed in both studies. For intravenous aciclovir the most commonly reported adverse effect was a reaction at the injection site (8 (16%) aciclovir versus 3 (7%) placebo; all patients, n = 97);…
  2 studies
  GRADE not reported

Aciclovir (oral or intravenous) for treatment vs placebo

The review found no eligible studies for this question.

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  For the treatment comparison (aciclovir versus placebo), no data were available for recurrence of lesions, amount of analgesia, days of stay in hospital, cost of oral care or patient quality of life.
  0 studies
  No studies found

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

The review found no eligible studies for this question.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  Minimum 3 months (planned)
  no estimate extracted
  0 studies
  No studies found

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

The review found no eligible studies for this question.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  Minimum 3 months (planned)
  no estimate extracted
  0 studies
  No studies found

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

Occlusal adjustment as an adjunct to non-surgical periodontal therapy showed no clear difference in probing (pocket) depth change (difference in mean reduction, mm) compared with non-surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  2 years
  MD 0.04 [-0.19, 0.27]
  1 study · 50 participants
  GRADE not reported

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

The review found no eligible studies for this question.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  Minimum 3 months (planned)
  no estimate extracted
  0 studies
  No studies found

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

The review found no eligible studies for this question.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  Minimum 3 months (planned)
  no estimate extracted
  0 studies
  No studies found

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

The review found no eligible studies for this question.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  Minimum 3 months (planned)
  no estimate extracted
  0 studies
  No studies found

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

Occlusal adjustment as an adjunct to surgical periodontal therapy led to higher clinical attachment level change (mean gain, mm) compared with surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  2 years
  MD 0.40 [0.05, 0.75]
  1 study · 50 participants
  GRADE not reported

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

The review found no eligible studies for this question.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  Minimum 3 months (planned)
  no estimate extracted
  0 studies
  No studies found

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

Occlusal adjustment as an adjunct to surgical periodontal therapy showed no clear difference in probing (pocket) depth change (difference in mean reduction, mm) compared with surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  2 years
  MD 0.01 [-0.20, 0.22]
  1 study · 50 participants
  GRADE not reported

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

Occlusal adjustment as an adjunct to non-surgical periodontal therapy led to higher clinical attachment level change (mean gain, mm) compared with non-surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  2 years
  MD 0.38 [0.04, 0.72]
  1 study · 50 participants
  GRADE not reported

Primary closure of the extraction socket with a mucoperiosteal flap vs Application of platelet-rich fibrin (PRF) without primary closure

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  90 days
  All participants had complete mucosal coverage without any signs of MRONJ at the final control examination 90 days postoperatively (77 randomised; 1 RCT); no case of postoperative MRONJ in either group; effect not…
  1 study · 77 participants
  GRADE not reported

Teriparatide 20 microg daily in addition to standard care vs placebo + standard care

Teriparatide 20 microg daily in addition to standard care showed no clear difference in healing of MRONJ (resolution of lesions) compared with placebo in addition to standard care (low certainty).

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  52 weeks
  RR 0.96 [0.31, 2.95]
  1 study · 33 participants
  Low

Concentrated growth factor (CGF) and primary wound closure vs primary closure

It is very uncertain whether concentrated growth factor (CGF) and primary wound closure changes healing of MRONJ (soft tissue healing) compared with primary wound closure only (very low certainty).

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes

  6 months
  RR 1.38 [0.81, 2.34]
  1 study · 28 participants
  Very low

Delicate surgery and wound closure by primary intention vs Non-traumatic tooth avulsion and wound closure by secondary intention

• Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes
  In both study arms, no case of postoperative MRONJ was observed (700 participants; 1 RCT); effect not estimable.
  1 study · 700 participants
  GRADE not reported