Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

461 questions · 473 findings · 36 reviews · HIV/AIDS

No studies found 38 · 8%GRADE not reported 9 · 1.9%Very low 126 · 26.6%Low 127 · 26.8%Moderate 152 · 32.1%High 21 · 4.4%

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Death · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes death compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality Death reports · Children with HIV infection

The intervention probably leads to lower all‐cause mortality Death reports (moderate certainty).

1 finding from 1 review

Intervention not reported

All clinic visits ‐ URI · Children with HIV infection

The intervention showed no clear difference in all clinic visits ‐ URI (moderate certainty).

1 finding from 1 review

Intervention not reported

All clinic visits ‐ pneumonia · Children with HIV infection

The intervention showed no clear difference in all clinic visits ‐ pneumonia (moderate certainty).

1 finding from 1 review

Intervention not reported

All clinic visits ‐ ear infection · Children with HIV infection

The intervention showed no clear difference in all clinic visits ‐ ear infection (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality at 12 months · Children with HIV infection

The intervention showed no clear difference in mortality at 12 months (moderate certainty).

1 finding from 1 review

Intervention not reported

Child growth at 12 months ‐ Wasting Anthropometric measurements at monthly clinic visits · Children with HIV infection

The intervention showed no clear difference in child growth at 12 months ‐ Wasting Anthropometric measurements at… (low certainty).

1 finding from 1 review

Intervention not reported

Child growth at 12 months ‐ Stunting Anthropometric measurements at monthly clinic visits · Children with HIV infection

The intervention showed no clear difference in child growth at 12 months ‐ Stunting Anthropometric measurements at… (low certainty).

1 finding from 1 review

Intervention not reported

Mortality at 9 months Hospital records and verbal autopsies · Children with HIV infection

The intervention showed no clear difference in mortality at 9 months Hospital records and verbal autopsies (low certainty).

1 finding from 1 review

Intervention not reported

All clinic visits ‐ watery diarrhoea · Children with HIV infection

The intervention probably leads to lower all clinic visits ‐ watery diarrhoea (moderate certainty).

1 finding from 1 review