Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

297 questions · 299 findings · 41 reviews · Neonatal

No studies found 31 · 10.4%GRADE not reported 15 · 5%Very low 52 · 17.4%Low 116 · 38.8%Moderate 76 · 25.4%High 9 · 3%

Intervention not reported

Failure to close a patent ductus arteriosus (PDA) (after single or 3 doses) · preterm infants with patent ductus arteriosus

The intervention showed no clear difference in failure to close a patent ductus arteriosus (PDA) (after single or 3… (moderate certainty).

1 finding from 1 review

Inhaled steroids vs systemic corticosteroids

BPD or death at 36 weeks' postmenstrual age№ of participants: 0 (0 RCTs) · preterm infants with respiratory distress for initial respiratory support

Inhaled steroids showed no clear difference in death or BPD at 36 weeks' postmenstrual age among all randomised compared with systemic corticosteroids (moderate certainty).

1 finding from 1 review

Inhaled steroids vs systemic corticosteroids

Death or BPD (28 days) · preterm infants with respiratory distress for initial respiratory support

Inhaled steroids showed no clear difference in death or BPD at 28 days compared with systemic corticosteroids (low certainty).

1 finding from 1 review

Inhaled steroids vs systemic corticosteroids

Bronchopulmonary dysplasia/chronic lung disease · preterm infants with respiratory distress for initial respiratory support

Inhaled steroids showed no clear difference in BPD at 36 weeks' postmenstrual age compared with systemic corticosteroids (moderate certainty).

1 finding from 1 review