Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

973 questions · 1,024 findings · 106 reviews

No studies found 235 · 22.9%GRADE not reported 59 · 5.8%Very low 207 · 20.2%Low 271 · 26.5%Moderate 177 · 17.3%High 75 · 7.3%

Topical vitamin D derivative vs placebo

Proportion of participants with adverse effects ‐ measured over 8 weeks · chronic palmoplantar pustulosis

Topical vitamin D derivative showed no clear difference in proportion of participants with adverse effects ‐ measured over 8… compared with placebo (moderate certainty).

1 finding from 1 review

Topical vitamin D derivative vs placebo

Proportion of participants cleared or almost cleared ‐ · chronic palmoplantar pustulosis

Topical vitamin D derivative may leads to higher proportion of participants cleared or almost cleared in the short… compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality in trials using vitamin D3 (cholecalciferol) ( · adults

The intervention probably leads to lower all‐cause mortality in trials using vitamin D3 (cholecalciferol) ( (moderate certainty).

1 finding from 1 review

Intervention not reported

Cardiovascular mortality in trials using vitamin D3 (cholecalciferol) ( · adults

The intervention showed no clear difference in cardiovascular mortality in trials using vitamin D3… (low certainty).

1 finding from 1 review

Intervention not reported

Cancer mortality in trials using vitamin D3 (cholecalciferol) ( · adults

The intervention probably leads to lower cancer mortality in trials using vitamin D3 (cholecalciferol) ( (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events: nephrolithiasis in trials using vitamin D3 combined with calcium ( · adults

The intervention probably leads to higher adverse events: nephrolithiasis in trials using vitamin D3 combined… (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events: hypercalcaemia in trials using the active forms of vitamin D (alfacalcidol and calcitriol) ( · adults

The intervention may leads to higher adverse events: hypercalcaemia in trials using the active forms of… (low certainty).

1 finding from 1 review

Neonatal vitamin A supplementation vs control

Vitamin A deficiency · mortality and morbidity in term neonates

Neonatal vitamin A supplementation showed no clear difference in vitamin A deficiency (serum retinol < 0.70 micromol/L) at 6 weeks of… compared with control (high certainty).

2 findings from 1 review

Multivitamin plus iron plus folate vs iron plus folate

Total fetal loss (including miscarriages or combined miscarriages and stillbirths) · pregnant women

Multivitamin plus iron plus folate showed no clear difference in total fetal loss (including miscarriages or combined miscarriages… compared with iron plus folate (high certainty).

1 finding from 1 review

Staple foods fortified with vitamin A vs same unfortified staple foods

Subclinical vitamin A deficiency (serum/plasma retinol 70 μmol/L or less) · general population over 2 years of age

It is very uncertain whether staple foods fortified with vitamin A changes subclinical vitamin A deficiency (serum/plasma retinol 70 μmol/L or… compared with same unfortified staple foods (very low certainty).

1 finding from 1 review

Staple foods fortified with vitamin A vs same unfortified staple foods

Clinical vitamin A deficiency (as defined by night blindness) · general population over 2 years of age

It is very uncertain whether staple foods fortified with vitamin A changes clinical vitamin A deficiency (defined as night blindness) compared with same unfortified staple foods (very low certainty).

1 finding from 1 review