Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

502 questions · 522 findings · 57 reviews

No studies found 184 · 35.2%GRADE not reported 153 · 29.3%Very low 86 · 16.5%Low 51 · 9.8%Moderate 38 · 7.3%High 10 · 1.9%

Non-surgical orthodontic treatment (any: facemask, chin cup, tandem traction bow, mandibular headgear, ORTA, reverse Twin Block, Reverse Forsus) vs no treatment

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Non-surgical orthodontic treatment (any: facemask, chin cup, tandem… probably leads to higher ANB compared with no treatment (moderate certainty).

1 finding from 1 review

Single-visit root canal treatment vs Multiple-visit root canal treatment (two or more visits)

Tooth extraction due to endodontic problems · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption

It is very uncertain whether single-visit root canal treatment changes tooth extraction due to endodontic problems compared with multiple-visit root canal treatment (two or more visits) (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs OnabotulinumtoxinA 20U

Physician assessment of success by analysing scores and scales ‐ 4 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines

Summary of Findings Table ‐ AbobotulinumtoxinA 50U showed no clear difference in physician assessment of success by analysing scores and scales ‐ 4… compared with onabotulinumtoxinA 20U (high certainty).

1 finding from 1 review

Summary of Findings Table ‐ IncobotulinumtoxinA 24U vs OnabotulinumtoxinA 24U

Physician assessment of success by analysing scores and scales ‐ 4 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines

Summary of Findings Table ‐ IncobotulinumtoxinA 24U showed no clear difference in physician assessment of success by analysing scores and scales ‐ 4… compared with onabotulinumtoxinA 24U (low certainty).

1 finding from 1 review

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo

Participant assessment of success by analysing scores and scales ‐ 4 weeks · glabellar lines

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U probably leads to higher participant assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo

Physician assessment of success by analysing scores and scales ‐ 4 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U probably leads to higher physician assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of Findings Table ‐ AbobotulinumtoxinA 50U vs placebo

Participant assessment of success by analysing scores and scales ‐ 20 weeks (Validated tools, wrinkles and lines at maximum contraction) · glabellar lines

Summary of Findings Table ‐ AbobotulinumtoxinA 50U leads to higher participant assessment of success by analysing scores and scales ‐… compared with placebo (high certainty).

1 finding from 1 review

Intervention not reported

Maternal pain score or pain measured in labour (VAS at 60 minutes (at peak of contraction))
1 finding from 1 review

Baclofen vs placebo

Neuromusculoskeletal and movement‐related functions up to 6 hours after treatment (Measured by spasm and deep tendon reflex scores, 0‐5, with 0 being no reflexes and 5 being clonus, or repeated involuntary muscle contractions) · adults with traumatic brain injury with spasticity in their arms and legs
1 finding from 1 review

Cuffed vs uncuffed tubes

Postextubation stridor (defined as any inspiratory sound or persistent barking, or presence of sternal or intercostal retractions postextubation) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes postextubation stridor (defined as any inspiratory sound or… compared with uncuffed tubes (very low certainty).

1 finding from 1 review

Single full-coverage metal-ceramic crown over composite core and post vs Direct adhesive composite restoration with post (conventional filling, no crown)

Catastrophic failure of the restored tooth or restoration leading directly to extraction · People with a permanent tooth that has undergone endodontic (root canal) treatment
1 finding from 1 review

Micro-invasive treatment (proximal sealing or resin infiltration): resin sealant, glass ionomer sealant, polyurethane/adhesive patch, or resin infiltration vs Non-invasive / control treatment

Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…

Micro-invasive treatment (proximal sealing or resin infiltration):… probably leads to lower caries (lesion) progression measured by digital subtraction… compared with non-invasive measures (e.g. fluoride varnish, flossing/oral hygiene… (moderate certainty).

1 finding from 1 review

Repair of a defective amalgam restoration in a permanent molar or premolar tooth (with amalgam) vs Replacement of a defective amalgam restoration in a permanent molar or premolar tooth (with amalgam)

Extraction of tooth (due to decay) · Adults (16 years or over) with one or more defective amalgam restoration(s) in a molar or premolar tooth/teeth

The review found no eligible studies for this question.

1 finding from 1 review

Repair of a defective resin composite restoration in a permanent molar or premolar tooth (with resin composite) vs Replacement of a defective resin composite restoration in a permanent molar or premolar tooth (with resin composite)

Extraction of tooth (due to decay) · Adults (16 years or over) with one or more defective resin composite restoration(s) in a molar or premolar tooth/teeth

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Maximum voluntary contraction in dystrophinopathies % · patients with muscular dystrophies
1 finding from 1 review

Intervention not reported

Maximum voluntary contraction in myotonic dystrophy type 1 % · patients with muscular dystrophies
1 finding from 1 review

Intervention not reported

Maximum voluntary contraction in myotonic dystrophy type 2 % · patients with muscular dystrophies
1 finding from 1 review