Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

749 questions · 769 findings · 63 reviews · Headline outcomes only

No studies found 202 · 26.3%GRADE not reported 31 · 4%Very low 172 · 22.4%Low 211 · 27.4%Moderate 106 · 13.8%High 47 · 6.1%

Intervention not reported

Utilisation of research (4 obstetric practices: use of polyglycolic acid sutures, ventouse for instrumental delivery, prophylactic antibiotics in caesarean section, and prophylactic corticosteroids in preterm deliveries).2 · Healthcare decision makers, health system managers or policy makers
1 finding from 1 review

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Requirement of other courses of antibiotics · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in requirement of other courses of antibiotics compared with continuation (low certainty).

1 finding from 1 review

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Incidence of S pneumoniae Confirmed bacterial infection · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in incidence of S pneumoniae Confirmed bacterial infection compared with continuation (low certainty).

1 finding from 1 review

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Nausea and vomiting · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in adverse effects: incidences of nausea and vomiting compared with continuation (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Adverse event nausea and vomiting (0 to 24 hours) · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in gastrointestinal side effects (nausea and/or vomiting) compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Complete abortion rate · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in complete abortion rate compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Unscheduled contact with care · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in unscheduled contact with care compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Patient satisfaction with abortion care overall ‐ not reported · women having medical abortion before 14 weeks' gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in patient satisfaction with abortion care overall compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

1 finding from 1 review