Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,841 questions · 1,893 findings · 109 reviews · Headline outcomes only

No studies found 546 · 28.8%GRADE not reported 117 · 6.2%Very low 613 · 32.4%Low 473 · 25%Moderate 118 · 6.2%High 26 · 1.4%

Single component intervention vs control

Exacerbations (number of people experiencing ≥ 1 exacerbations) · COPD

It is very uncertain whether single component intervention changes exacerbations: number of people experiencing exacerbations compared with control (very low certainty).

1 finding from 1 review

Single component intervention vs control

Adverse events: number of people experiencing adverse events (all cause or COPD‐related), serious adverse events, mortality · COPD

It is very uncertain whether single component intervention changes adverse events: number of people experiencing adverse events (all… compared with control (very low certainty).

1 finding from 1 review

Valproate vs placebo or no intervention

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether valproate changes benzodiazepine discontinuation, end of intervention compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Paroxetine vs placebo or no intervention

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether paroxetine changes benzodiazepine discontinuation, end of intervention compared with placebo or no intervention (very low certainty).

1 finding from 1 review