evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

260 questions · 265 findings · 20 reviews · Pregnancy and Childbirth

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 57 · 21.5%GRADE not reported 29 · 10.9%Very low 77 · 29.1%Low 85 · 32.1%Moderate 16 · 6%High 1 · 0.4%

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

Preterm birth · pregnant women

(Infant outcomes) Any supplements containing iron and folic acid showed no clear difference in preterm birth (less than 37 weeks of gestation) (ALL) compared with same supplements without iron nor folic acid (no iron nor folic acid… (low certainty).

1 finding from 1 review

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

Neonatal death (death within the first 28 days of life) · pregnant women

(Infant outcomes) Any supplements containing iron and folic acid showed no clear difference in neonatal death (within 28 days after delivery) (ALL) compared with same supplements without iron nor folic acid (no iron nor folic acid… (low certainty).

1 finding from 1 review

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

Any congenital anomalies · pregnant women

(Infant outcomes) Any supplements containing iron and folic acid showed no clear difference in congenital anomalies (ALL) compared with same supplements without iron nor folic acid (no iron nor folic acid… (low certainty).

1 finding from 1 review

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) (ALL) · pregnant women

(Maternal outcomes) Any supplements containing iron and folic acid probably leads to lower maternal anaemia at term (Hb less than 110 g/L at 37 weeks'… compared with same supplements without iron nor folic acid (no iron nor folic acid… (moderate certainty).

1 finding from 1 review

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

Iron deficiency at term (as defined by trialists, based on any indicator of iron status at 37 wk gestation or more) · pregnant women

(Maternal outcomes) Any supplements containing iron and folic acid may leads to lower maternal iron deficiency at term (as defined by trialists, based on… compared with same supplements without iron nor folic acid (no iron nor folic acid… (low certainty).

1 finding from 1 review

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

Side effects (any reported throughout the intervention period) (ALL) · pregnant women

(Maternal outcomes) Any supplements containing iron and folic acid probably leads to higher side effects (any reported throughout the intervention period) (ALL) compared with same supplements without iron nor folic acid (no iron nor folic acid… (moderate certainty).

1 finding from 1 review

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

Maternal severe anaemia at any time during 2nd or 3rd trimester (Hb less than 70 g/L) · pregnant women

It is very uncertain whether (Maternal outcomes) Any supplements containing iron and folic acid changes maternal severe anaemia at any time during second and third… compared with same supplements without iron nor folic acid (no iron nor folic acid… (very low certainty).

1 finding from 1 review

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

Infection during pregnancy (including urinary tract infections and others) (ALL) · pregnant women

It is very uncertain whether (Maternal outcomes) Any supplements containing iron and folic acid changes infection during pregnancy (including urinary tract infections) (ALL) compared with same supplements without iron nor folic acid (no iron nor folic acid… (very low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Preterm birth · pregnant women

(Infant outcomes) Any supplements containing iron showed no clear difference in preterm birth (less than 37 weeks of gestation) (ALL) compared with same supplements without iron or no treatment/placebo (no iron or… (moderate certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Neonatal death (death within the first 28 days of life) · pregnant women

(Infant outcomes) Any supplements containing iron showed no clear difference in neonatal death (within 28 days after delivery) (ALL) compared with same supplements without iron or no treatment/placebo (no iron or… (low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Any congenital anomalies · pregnant women

(Infant outcomes) Any supplements containing iron showed no clear difference in congenital anomalies (ALL) compared with same supplements without iron or no treatment/placebo (no iron or… (low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) (ALL) · pregnant women

(Maternal outcomes) Any supplements containing iron may leads to lower maternal anaemia at term (Hb less than 110 g/L at 37 weeks'… compared with same supplements without iron or no treatment/placebo (no iron or… (low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Iron deficiency at term (as defined by trialists, based on any indicator of iron status at 37 wk gestation or more) · pregnant women

(Maternal outcomes) Any supplements containing iron may leads to lower maternal iron deficiency at term (as defined by as defined by… compared with same supplements without iron or no treatment/placebo (no iron or… (low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Maternal death · pregnant women

It is very uncertain whether (Maternal outcomes) Any supplements containing iron changes maternal death (death while pregnant or within 42 days of… compared with same supplements without iron or no treatment/placebo (no iron or… (very low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Side effects (any reported throughout the intervention period) (ALL) · pregnant women

It is very uncertain whether (Maternal outcomes) Any supplements containing iron changes side effects (any reported throughout the intervention period) (ALL) compared with same supplements without iron or no treatment/placebo (no iron or… (very low certainty).

1 finding from 1 review

Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes)

Neural tube defects (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention

Supplementation with folate leads to lower neural tube defects (All) compared with no intervention, placebo or other micronutrients without folate… (high certainty).

1 finding from 1 review

Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes)

Miscarriage · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention

Supplementation with folate showed no clear difference in miscarriage (All) compared with no intervention, placebo or other micronutrients without folate… (moderate certainty).

1 finding from 1 review