Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

330 questions · 337 findings · 33 reviews

No studies found 96 · 28.5%GRADE not reported 53 · 15.7%Very low 80 · 23.7%Low 63 · 18.7%Moderate 39 · 11.6%High 6 · 1.8%

Total daily fluoride intake (TDFI) and daily fluoride intake from toothpaste

Correlation between daily urinary fluoride excretion (DUFE) and fluoride intake · Children and adults with 24-h urinary fluoride monitoring (9 studies reporting both intake and urine; Table 2)

Daily urinary fluoride excretion was not correlated with total daily fluoride intake or with fluoride intake from toothpaste (R2 < 0.07), based on nine studies (ungraded).

1 finding from 1 review
  • Fluoride Intake Through Dental Care Products: A Systematic Review. 2022 All outcomes
    24-h urine collection · Multiple countries (28 studies; ~43% conducted in Brazil); community/general-population settings · High-fluoride-area data from Idowu et al. [46,47] excluded
    R2 (coefficient of determination) <0.07
    9 studies
    GRADE not reported

Anaesthesia depth monitors (BIS and M‐entropy) vs standard monitoring

Awareness Postoperative interview · patients with prevention of recall of events during surgery

Anaesthesia depth monitors (BIS and M‐entropy) showed no clear difference in awareness Postoperative interview compared with standard clinical and electronic monitoring (low certainty).

1 finding from 1 review

Anaesthesia depth monitors (BIS and M‐entropy) vs standard monitoring

Adverse effects of intraoperative wakefulness and/or postoperative awareness (i.e. post‐traumatic stress syndrome, myocardial infarction, cardiac arrest, etc.) · patients with prevention of recall of events during surgery

The review found no eligible studies for this question.

1 finding from 1 review