Findings

What do systematic reviews say?

632 questions · 636 findings · 33 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 197 · 31%GRADE not reported 13 · 2%Very low 133 · 20.9%Low 159 · 25%Moderate 121 · 19%High 13 · 2%

Autogenic drainage vs conventional physiotherapy

Exercise capacity · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autogenic drainage vs conventional physiotherapy

Adverse events · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autogenic drainage vs conventional physiotherapy

Hospital admissions · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 36 participants
Very low

Autogenic drainage vs conventional physiotherapy

Need for extra treatment · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 36 participants
Very low

Oscillating devices vs conventional physiotherapy

FEV1 % predicted · adults and children with cystic fibrosis

1 finding from 1 review

Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 363 participants
Very low

Oscillating devices vs conventional physiotherapy

FEF25-75 · adults and children with cystic fibrosis

1 finding from 1 review

Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 319 participants
Very low

Oscillating devices vs conventional physiotherapy

FVC · adults and children with cystic fibrosis

1 finding from 1 review

Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 268 participants
Very low

Oscillating devices vs conventional physiotherapy

Sputum: volume · adults and children with cystic fibrosis

1 finding from 1 review

Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 17 participants
Low

Oscillating devices vs conventional physiotherapy

Sputum: weight (dry or wet) (g) · adults and children with cystic fibrosis

1 finding from 1 review

Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 188 participants
Very low

Oscillating devices vs conventional physiotherapy

Frequency of exacerbationsb · adults and children with cystic fibrosis

1 finding from 1 review

Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 262 participants
Very low

Oscillating devices vs conventional physiotherapy

Participant‐reported satisfaction with treatment intervention · adults and children with cystic fibrosis

1 finding from 1 review

Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 345 participants
Very low

Summary of findings: cycled vs culture‐based antibiotic therapy

Time to next isolation of PA · children (aged 1 to 12 years) with CF and a newly isolated PA infection

Summary of findings: cycled probably leads to higher time to next isolation of PA compared with culture‐based antibiotic therapy (moderate certainty).

1 finding from 1 review

Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
HR 2.04 [1.28, 3.26]
1 study · 253 participants
Moderate

Summary of findings: cycled vs culture‐based antibiotic therapy

Quality of life · children (aged 1 to 12 years) with CF and a newly isolated PA infection

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: cycled vs culture‐based antibiotic therapy

Lung function: FEV1 mL (change from baseline) · children (aged 1 to 12 years) with CF and a newly isolated PA infection

1 finding from 1 review

Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 131 participants
Very low

Summary of findings: cycled vs culture‐based antibiotic therapy

Pulmonary exacerbations · children (aged 1 to 12 years) with CF and a newly isolated PA infection

1 finding from 1 review

Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 253 participants
Moderate

Summary of findings: cycled vs culture‐based antibiotic therapy

Time to chronic PA · children (aged 1 to 12 years) with CF and a newly isolated PA infection

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: cycled vs culture‐based antibiotic therapy

Adverse events: severe adverse events (total) · children (aged 1 to 12 years) with CF and a newly isolated PA infection

Summary of findings: cycled showed no clear difference in adverse events: severe adverse events (total) compared with culture‐based antibiotic therapy (moderate certainty).

1 finding from 1 review

Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
RR 0.65 [0.39, 1.11]
1 study · 253 participants
Moderate

Summary of findings: cycled vs culture‐based antibiotic therapy

Emergence of novel bacteria: isolation of novel gram negative organisms · children (aged 1 to 12 years) with CF and a newly isolated PA infection

Summary of findings: cycled showed no clear difference in emergence of novel bacteria: isolation of novel gram negative… compared with culture‐based antibiotic therapy (moderate certainty).

1 finding from 1 review

Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
RR 1 [0.67, 1.5]
1 study · 253 participants
Moderate

CCPT vs PEP

FEV1 (% predicted): mean change from baseline · adults and children with cystic fibrosis

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 169 participants
Very low

CCPT vs extrapulmonary mechanical percussion

FEF25–75: rate of decline in FEF25–75 · adults and children with cystic fibrosis

1 finding from 1 review

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 151 participants
Very low