Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

618 questions · 646 findings · 79 reviews · Neonatal

No studies found 73 · 11.3%GRADE not reported 29 · 4.5%Very low 145 · 22.4%Low 177 · 27.4%Moderate 173 · 26.8%High 49 · 7.6%

Intervention not reported

Invasive infection prior to hospital discharge · very preterm (< 32 weeks' gestation) or very low birth weight (< 1500 g) infants

The intervention probably leads to higher invasive infection prior to hospital discharge (moderate certainty).

1 finding from 1 review

Paracetamol vs ibuprofen

Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm or low birth weight infants with PDA

Paracetamol showed no clear difference in failure of PDA closure after first course of treatment (assessed by… compared with ibuprofen (moderate certainty).

1 finding from 1 review