Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

676 questions · 705 findings · 98 reviews · Headline outcomes only

No studies found 183 · 26%GRADE not reported 47 · 6.7%Very low 209 · 29.6%Low 153 · 21.7%Moderate 85 · 12.1%High 28 · 4%

Acetazolamide vs placebo

Incidence of acute mountain sickness (AMS)‐ Follow‐ up: From arrival to 24 hours later · participants at risk of high altitude illness

Acetazolamide probably leads to lower incidence of acute mountain sickness (AMS)‐ Follow‐ up: From arrival… compared with placebo (moderate certainty).

1 finding from 1 review

Dexamethasone vs placebo

Incidence of acute mountain sickness (AMS)‐ Follow‐ up: From arrival to 24 hours later · participants at risk of high altitude illness

Dexamethasone showed no clear difference in incidence of acute mountain sickness (AMS)‐ Follow‐ up: From arrival… compared with placebo (low certainty).

1 finding from 1 review

Acetazolamide vs placebo

Incidence of high altitude cerebral oedema (HACE) ‐ not reported · participants at risk of high altitude illness

Acetazolamide showed no clear difference in incidence of high altitude cerebral oedema (HACE)‐ Follow‐ up: From… compared with placebo (moderate certainty).

1 finding from 1 review

Acetazolamide vs placebo

Adverse events: Paresthesias‐ Follow‐ up: From arrival to 24 hours later · participants at risk of high altitude illness

Acetazolamide may leads to higher adverse events: Paresthesias‐ Follow‐ up: From arrival to 24 hours… compared with placebo (low certainty).

1 finding from 1 review

Budesonide vs placebo

Incidence of acute mountain sickness (AMS)‐ Follow‐ up: From arrival to 24 hours later · participants at risk of high altitude illness

Budesonide may leads to lower incidence of acute mountain sickness (AMS)‐ Follow‐ up: From arrival… compared with placebo (low certainty).

1 finding from 1 review

Insulin vs anti‐diabetic agent

Perinatal (fetal and neonatal death) and later infant mortality · Infants of women diagnosed with gestational diabetes

Insulin showed no clear difference in perinatal (fetal and neonatal death) and later infant mortality compared with anti‐diabetic agent (low certainty).

1 finding from 1 review