What do systematic reviews say?

Antiplatelet agent vs placebo

Antiplatelet agent showed no clear difference in adverse events (not reported) compared with placebo (low certainty).

• Pharmacological interventions for asymptomatic carotid stenosis 2023 · Cochrane Headline outcomes only
  RR 0.81 [0.41, 1.59]
  1 study · 372 participants
  Low

Antiplatelet agent vs placebo

The review found no eligible studies for this question.

• Pharmacological interventions for asymptomatic carotid stenosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antihypertensive agent vs placebo

The review found no eligible studies for this question.

• Pharmacological interventions for asymptomatic carotid stenosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Thrombo‐aspiration alone showed no clear difference in functional independence at 3 months (mRS 0 to 2) (primary outcome) compared with stent‐retrieval thrombectomy alone (high certainty).

• Different types of percutaneous endovascular interventions for acute ischemic stroke 2023 · Cochrane Headline outcomes only
  RR 0.97 [0.82, 1.13]
  2 studies · 633 participants
  High

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Thrombo‐aspiration alone showed no clear difference in successful reperfusion (mTICI 2b to 3) postprocedure compared with stent‐retrieval thrombectomy alone (high certainty).

• Different types of percutaneous endovascular interventions for acute ischemic stroke 2023 · Cochrane Headline outcomes only
  RR 1.01 [0.95, 1.07]
  2 studies · 650 participants
  High

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Thrombo‐aspiration alone showed no clear difference in all‐cause mortality within 3 months compared with stent‐retrieval thrombectomy alone (high certainty).

• Different types of percutaneous endovascular interventions for acute ischemic stroke 2023 · Cochrane Headline outcomes only
  RR 1.01 [0.74, 1.37]
  2 studies · 633 participants
  High

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Thrombo‐aspiration alone showed no clear difference in intracranial hemorrhage on imaging at 24 hours compared with stent‐retrieval thrombectomy alone (high certainty).

• Different types of percutaneous endovascular interventions for acute ischemic stroke 2023 · Cochrane Headline outcomes only
  RR 1.03 [0.86, 1.24]
  2 studies · 645 participants
  High

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Thrombo‐aspiration alone showed no clear difference in symptomatic intracranial hemorrhage at 24 hours compared with stent‐retrieval thrombectomy alone (high certainty).

• Different types of percutaneous endovascular interventions for acute ischemic stroke 2023 · Cochrane Headline outcomes only
  RR 0.9 [0.49, 1.68]
  2 studies · 645 participants
  High

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Thrombo‐aspiration alone showed no clear difference in procedure‐related adverse events within 3 months compared with stent‐retrieval thrombectomy alone (high certainty).

• Different types of percutaneous endovascular interventions for acute ischemic stroke 2023 · Cochrane Headline outcomes only
  RR 0.98 [0.68, 1.41]
  2 studies · 651 participants
  High

Prism adaptation training vs control

The review found no eligible studies for this question.

• Non‐pharmacological interventions for spatial neglect or inattention following stroke and other non‐progressive brain… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prism adaptation training vs control

It is very uncertain whether prism adaptation training changes activities of daily living: immediate effects compared with any control (very low certainty).

• Non‐pharmacological interventions for spatial neglect or inattention following stroke and other non‐progressive brain… 2021 · Cochrane Headline outcomes only
  SMD 0.2
  5 studies · 158 participants
  Very low
• Non‐pharmacological interventions for spatial neglect or inattention following stroke and other non‐progressive brain… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 39 participants
  Very low

Prism adaptation training vs control

It is very uncertain whether prism adaptation training changes neglect outcomes: effects persisting at least 1 month post… compared with any control (very low certainty).

• Non‐pharmacological interventions for spatial neglect or inattention following stroke and other non‐progressive brain… 2021 · Cochrane Headline outcomes only
  SMD 0.05
  1 study · 16 participants
  Very low

Prism adaptation training vs control

It is very uncertain whether prism adaptation training changes neglect outcomes: immediate effects compared with any control (very low certainty).

• Non‐pharmacological interventions for spatial neglect or inattention following stroke and other non‐progressive brain… 2021 · Cochrane Headline outcomes only
  SMD 0.28
  5 studies · 154 participants
  Very low

Prism adaptation training vs control

The review found no eligible studies for this question.

• Non‐pharmacological interventions for spatial neglect or inattention following stroke and other non‐progressive brain… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NIBS vs control

The review found no eligible studies for this question.

• Non‐pharmacological interventions for spatial neglect or inattention following stroke and other non‐progressive brain… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NIBS vs control

It is very uncertain whether NIBS changes activities of daily living: effects persisting at least 1 month post… compared with any control (very low certainty).

• Non‐pharmacological interventions for spatial neglect or inattention following stroke and other non‐progressive brain… 2021 · Cochrane Headline outcomes only
  SMD 0.35
  3 studies · 92 participants
  Very low
• Non‐pharmacological interventions for spatial neglect or inattention following stroke and other non‐progressive brain… 2021 · Cochrane Headline outcomes only
  SMD 0.61
  6 studies · 160 participants
  Very low

NIBS vs control

The review found no eligible studies for this question.

• Non‐pharmacological interventions for spatial neglect or inattention following stroke and other non‐progressive brain… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NIBS vs control

It is very uncertain whether NIBS changes neglect outcomes: effects persisting at least 1 month post… compared with any control (very low certainty).

• Non‐pharmacological interventions for spatial neglect or inattention following stroke and other non‐progressive brain… 2021 · Cochrane Headline outcomes only
  SMD 0.77
  3 studies · 102 participants
  Very low

NIBS vs control

It is very uncertain whether NIBS changes neglect outcomes: immediate effects compared with any control (very low certainty).

• Non‐pharmacological interventions for spatial neglect or inattention following stroke and other non‐progressive brain… 2021 · Cochrane Headline outcomes only
  SMD 0.75
  10 studies · 244 participants
  Very low

NIBS vs control

• Non‐pharmacological interventions for spatial neglect or inattention following stroke and other non‐progressive brain… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 24 participants
  GRADE not reported