Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,078 questions · 1,098 findings · 33 reviews · Skin

No studies found 396 · 36.1%GRADE not reported 89 · 8.1%Very low 181 · 16.5%Low 183 · 16.7%Moderate 196 · 17.9%High 53 · 4.8%

Extracorporeal photopheresis vs PUVA

Objective response rate · people with mycosis fungoides

It is very uncertain whether extracorporeal photopheresis changes objective response rate (Time point of measurement: three months of… compared with PUVA (very low certainty).

1 finding from 1 review

Intervention not reported

Transepidermal water loss (TEWL) Measured using temperature‐adjusted g/m²/h with the Tewameter TM 300 (Courage + Khazaka, Cologne, Germany) Hahnel 2017: measured at 56 ± 4 days Shishido 2017: measured 15 minutes after wiping the skin with a dry to... · people 60 years of age and older
1 finding from 1 review

Intervention not reported

Stratum corneum hydration (SCH) (at baseline and day 56 ± 4) Hahnel 2017: measured at 56 ± 4 days in mid‐volar arm and lower leg in arbitrary units from 0 (no water) to 120 (on water) using the Corneometer CM 825 Gillis 2016: measured at 12 weeks ... · people 60 years of age and older
1 finding from 1 review

Intervention not reported

Clinical score of dryness Hahnel 2017: measured at day 56 ± 4 using the Overall Dry Skin Score Boccanfuso 1978: measured after 10 applications using a non‐validated General Foot Condition Questionnaire including a Dryness Scale (1 = oily; 2 = norm... · people 60 years of age and older
1 finding from 1 review

Triamcinolone acetonide 0.1% cream with occlusive dressing vs clobetasol cream 0.05% cream

Proportion of participants cleared or almost cleared ‐ · chronic palmoplantar pustulosis

It is very uncertain whether triamcinolone acetonide 0.1% cream with occlusive dressing changes proportion of participants cleared or almost cleared ‐ compared with clobetasol cream 0.05% cream (very low certainty).

1 finding from 1 review

Topical vitamin D derivative vs placebo

Proportion of participants with adverse effects ‐ measured over 8 weeks · chronic palmoplantar pustulosis

Topical vitamin D derivative showed no clear difference in proportion of participants with adverse effects ‐ measured over 8… compared with placebo (moderate certainty).

1 finding from 1 review