Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

572 questions · 579 findings · 55 reviews · Headline outcomes only

No studies found 60 · 10.4%GRADE not reported 42 · 7.3%Very low 205 · 35.4%Low 210 · 36.3%Moderate 52 · 9%High 10 · 1.7%

Fish oil lipid emulsion (LE) vs another fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MOFS‐LE vs MFS‐LE · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MOFS‐LE vs MFS‐LE compared with another fish oil LE (low certainty).

1 finding from 1 review

Alternative lipid emulsion (LE) vs S‐LE

PNALD/cholestasis (any definition) – OS‐LE vs S‐LE · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (any definition) – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

1 finding from 1 review

Alternative lipid emulsion (LE) vs S‐LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – OS‐LE vs S‐LE · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – all fish oil LE vs non‐fish oil LE (combined subgroups) · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – all fish oil LE… compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Alternative lipid emulsion (LE) vs another alternative‐LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MS‐LE vs OS‐LE · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MS‐LE vs OS‐LE compared with another alternative‐LE (low certainty).

1 finding from 1 review