Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

382 questions · 384 findings · 98 reviews

No studies found 54 · 14.1%GRADE not reported 37 · 9.6%Very low 116 · 30.2%Low 99 · 25.8%Moderate 60 · 15.6%High 18 · 4.7%

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Interruptions to cancer treatment (chemotherapy delays/discontinuations) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in interruptions to cancer treatment (chemotherapy… compared with placebo; GRADE not reported.

1 finding from 1 review

Intervention not reported

Adverse events leading to treatment discontinuation ( · adults and adolescents with pleural TB

The intervention may leads to higher adverse events leading to treatment discontinuation ( (low certainty).

1 finding from 1 review

Capecitabine vs 5‐FU‐containing regimens

Treatment discontinuation due to toxicity · people with advanced gastric cancer

Capecitabine showed no clear difference in treatment discontinuation due to toxicity compared with 5‐FU‐containing regimens (low certainty).

1 finding from 1 review

Taxane‐platinum‐fluoropyrimidine combinations vs taxane‐platinum (without fluoropyrimidine)

Treatment discontinuation due to toxicity · people with advanced gastric cancer

It is very uncertain whether taxane‐platinum‐fluoropyrimidine combinations changes treatment discontinuation due to toxicity compared with taxane‐platinum (without fluoropyrimidine) (very low certainty).

1 finding from 1 review

S‐1 vs 5‐FU‐containing regimens

Treatment discontinuation due to toxicity · people with advanced gastric cancer

S‐1 showed no clear difference in treatment discontinuation due to toxicity compared with 5‐FU‐containing regimens (high certainty).

1 finding from 1 review

Mefloquine vs doxycycline

Discontinuation of treatment due to side effects ( · Non‐immune adults and children travelling to malaria‐endemic settings

Mefloquine showed no clear difference in discontinuations due to adverse effects compared with doxycycline; GRADE not reported.

1 finding from 1 review

Mefloquine vs atovaquone‐proguanil

Discontinuation of medication due to adverse events · non‐immune adults and children travelling to or living in malaria‐endemic settings

Mefloquine led to higher discontinuation of drug due to adverse effects compared with atovaquone‐proguanil; GRADE not reported.

1 finding from 1 review

Neuroprotection vs control

Adverse effects: ocular allergy to the study medication requiring discontinuation up to 4 years' · people with open‐angle glaucoma

It is very uncertain whether neuroprotection changes adverse effects: ocular allergy to the study medication requiring… compared with control (very low certainty).

1 finding from 1 review