Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

695 questions · 728 findings · 63 reviews · Headline outcomes only

No studies found 219 · 30.1%GRADE not reported 55 · 7.6%Very low 194 · 26.6%Low 136 · 18.7%Moderate 90 · 12.4%High 34 · 4.7%

Topical ketanserin (2%) vs clioquinol cream (3%) or zinc paste

Ulcer healing · ulceration caused by nerve damage in leprosy

It is very uncertain whether topical ketanserin (2%) changes primary outcome: healing of ulcers (healing of ulcer at 3 months) compared with clioquinol cream (3%) or zinc paste (very low certainty).

1 finding from 1 review

Topical phenytoin vs saline dressing

Ulcer healing · ulceration and other skin changes caused by nerve damage in leprosy
2 findings from 1 review

Footwear ‐ canvas shoes vs PVC boots

Primary outcome: healing of ulcer (number of persons having ulcers not healed at 1 year) · ulceration and other skin changes caused by nerve damage in leprosy

It is very uncertain whether footwear ‐ canvas shoes changes primary outcome: healing of ulcer (number of persons having ulcers… compared with PVC boots (very low certainty).

1 finding from 1 review