Weight (z score) · infants and children with pulmonary exacerbations in cystic fibrosis
1 finding from 1 review
Number of positive P aeruginosa isolates · infants and children with pulmonary exacerbations in cystic fibrosis
1 finding from 1 review
Number or proportion of hospitalisations · infants and children with pulmonary exacerbations in cystic fibrosis
1 finding from 1 review
Hospital costs · infants and children with pulmonary exacerbations in cystic fibrosis
1 finding from 1 review
All‐cause mortality · people with bloodstream infections
Rapid susceptibility methods showed no clear difference in mortality compared with standard methods versus placebo (low certainty).
1 finding from 1 review
Mortality (subgroup genotypic) · people with bloodstream infections
Rapid susceptibility methods showed no clear difference in mortality (subgroup genotypic) compared with standard methods versus placebo (low certainty).
1 finding from 1 review
Mortality (subgroup phenotypic) · people with bloodstream infections
Rapid susceptibility methods showed no clear difference in mortality (subgroup phenotypic) compared with standard methods versus placebo (low certainty).
1 finding from 1 review
Mortality (with stewardship) · people with bloodstream infections
Rapid susceptibility methods showed no clear difference in mortality (with stewardship) compared with standard methods versus placebo (low certainty).
1 finding from 1 review
Mortality (without stewardship) · people with bloodstream infections
Rapid susceptibility methods showed no clear difference in mortality (without stewardship) compared with standard methods versus placebo (low certainty).
1 finding from 1 review
Time to hospital discharge · people with bloodstream infections
1 finding from 1 review
Time‐to‐appropriate antibiotic · people with bloodstream infections
1 finding from 1 review
Percentage of closed pockets · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Probing pocket depth · Adults with periodontitis (chronic and aggressive)
Azithromycin + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.
3 findings from 1 review
MD -0.57 [-1.08, -0.07]
6 studies · 216 participants
GRADE not reported
MD -0.77 [-2.33, 0.79]
2 studies · 110 participants
Very low
MD -0.60 [-1.02, -0.18]
7 studies · 258 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with metronidazole + SRP; GRADE not reported.
3 findings from 1 review
MD 0.34 [-0.08, 0.76]
3 studies · 75 participants
GRADE not reported
MD 1.10 [0.36, 1.84]
1 study · 27 participants
Very low
MD -0.12 [-0.72, 0.49]
2 studies · 49 participants
GRADE not reported
Probing pocket depth · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether metronidazole + SRP changes probing pocket depth compared with SRP (very low certainty).
3 findings from 1 review
MD -1.11 [-2.84, 0.61]
2 studies · 47 participants
Very low
MD -0.59 [-0.95, -0.23]
4 studies · 94 participants
GRADE not reported
MD -0.10 [-0.37, 0.16]
4 studies · 108 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
It is very uncertain whether doxycycline + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
3 findings from 1 review
MD -0.80 [-1.49, -0.11]
1 study · 22 participants
Very low
MD -0.61 [-1.14, -0.08]
3 studies · 65 participants
GRADE not reported
MD 0.15 [-0.53, 0.83]
2 studies · 43 participants
GRADE not reported
Percentage of closed pockets · Adults with periodontitis (chronic and aggressive)
Azithromycin + SRP showed no clear difference in percentage of closed pockets compared with SRP; GRADE not reported.
2 findings from 1 review
Probing pocket depth · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in probing pocket depth compared with SRP; GRADE not reported.
3 findings from 1 review
MD 0.10 [-0.29, 0.50]
2 studies · 43 participants
GRADE not reported
MD -1.00 [-1.78, -0.22]
1 study · 22 participants
Very low
MD -0.43 [-0.88, 0.01]
3 studies · 65 participants
GRADE not reported
Patient-reported quality of life changes · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Probing pocket depth · Adults with periodontitis (chronic and aggressive)
Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.
3 findings from 1 review
MD -0.47 [-0.68, -0.26]
6 studies · 215 participants
GRADE not reported
MD -0.18 [-0.33, -0.04]
15 studies · 562 participants
GRADE not reported
MD -0.30 [-0.42, -0.18]
2 studies · 389 participants
Very low