Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,536 questions · 2,637 findings · 315 reviews

No studies found 608 · 23.1%GRADE not reported 488 · 18.5%Very low 688 · 26.1%Low 540 · 20.5%Moderate 249 · 9.4%High 64 · 2.4%

Pre-operative and post-operative radiotherapy vs Post-operative radiotherapy alone

Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative and post-operative radiotherapy showed no clear difference in locoregional control compared with post-operative radiotherapy alone; GRADE not reported.

1 finding from 1 review

Immediate implants (placed in a fresh extraction socket just after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Prosthesis failure · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate implants (placed in a fresh extraction socket just after… showed no clear difference in prosthesis failure compared with delayed implants (placed at least 2 months after extraction, in…; GRADE not reported.

1 finding from 1 review

Immediate implants (placed in a fresh extraction socket just after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Aesthetics assessed by dentist: position of the perimplant tissues · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate implants (placed in a fresh extraction socket just after… led to lower aesthetics assessed by dentist: position of the perimplant tissues compared with delayed implants (placed at least 2 months after extraction, in…; GRADE not reported.

1 finding from 1 review

Pre-operative radiotherapy (plus surgery) vs surgery

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative radiotherapy (plus surgery) showed no clear difference in total mortality compared with surgery alone; GRADE not reported.

1 finding from 1 review

Immediate implants (placed in a fresh extraction socket just after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Implant failure · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate implants (placed in a fresh extraction socket just after… showed no clear difference in implant failure compared with delayed implants (placed at least 2 months after extraction, in…; GRADE not reported.

1 finding from 1 review

Pre-operative and post-operative radiotherapy vs Post-operative radiotherapy alone

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative and post-operative radiotherapy showed no clear difference in total mortality compared with post-operative radiotherapy alone; GRADE not reported.

1 finding from 1 review

GM-CSF vs povidone‐iodine

Time to heal mucositis (days) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Granulocyte macrophage-colony stimulating factor (GM-CSF) led to lower time to heal mucositis (days) compared with povidone iodine; GRADE not reported.

1 finding from 1 review

Pre-operative radiotherapy (plus surgery) vs surgery

Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative radiotherapy (plus surgery) showed no clear difference in locoregional control compared with surgery alone; GRADE not reported.

1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Time to complete healing · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)
1 finding from 1 review

Calcitonin (salmon calcitonin nasal spray 200 IU/day) vs placebo

Increase in volume of more than 10% compared to the pretreatment measurement · Patients with histologically confirmed CGCG in one or both jaws and normal serum calcium and parathyroid hormone (PTH) levels

Calcitonin (salmon calcitonin nasal spray 200 IU/day) showed no clear difference in increase in volume of more than 10% compared to the pretreatment… compared with placebo; GRADE not reported.

1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Recurrence of lesions · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)

The review found no eligible studies for this question.

1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Duration of viral shedding · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)
1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Relief of pain · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)
1 finding from 1 review