Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,752 questions · 6,648 findings · 688 reviews

No studies found 1,125 · 16.9%GRADE not reported 670 · 10.1%Very low 1,796 · 27%Low 1,685 · 25.3%Moderate 1,075 · 16.2%High 297 · 4.5%

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Erythromycin plus nasogastric tube lavage vs metoclopramide plus nasogastric tube lavage

Visualisation of gastric mucosa · people with acute UGIH

It is very uncertain whether erythromycin plus nasogastric tube lavage changes visualisation of gastric mucosa compared with metoclopramide plus nasogastric tube lavage (very low certainty).

1 finding from 1 review

Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or

5a. Moderate‐to‐severe neurodevelopmental disability or intellectual impairment after 2 years of age – doxapram compared to no treatment for the treatment of apnea · treatment of apnea

The review found no eligible studies for this question.

1 finding from 1 review

Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or

5b. Moderate‐to‐severe neurodevelopmental disability or intellectual impairment after 2 years of age – doxapram compared to alternative treatment for the treatment of apnea · treatment of apnea

The review found no eligible studies for this question.

1 finding from 1 review

Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or

1a.'Clinical apnea' after initiation of treatment – doxapram compared to no treatment for the prevention of reintubation · prevention of reintubation

The review found no eligible studies for this question.

2 findings from 1 review

Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or

2b. Failed apnea reduction after 2–7 days – doxapram compared to alternative treatment for the prevention of reintubation · prevention of reintubation

It is very uncertain whether doxapram changes 2b. Failed apnea reduction after 2–7 days – doxapram compared to… compared with no treatment, placebo, methylxanthine (including theophylline,… (very low certainty).

1 finding from 1 review

Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or

3a. Chronic lung disease at 36 weeks' postmenstrual age – doxapram compared to no treatment for the prevention of reintubation · prevention of reintubation

The review found no eligible studies for this question.

1 finding from 1 review

Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or

4a. Death (at any time during initial hospitalization) – doxapram compared to no treatment for the prevention of reintubation · prevention of reintubation

The review found no eligible studies for this question.

1 finding from 1 review

Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or

4b. Death (at any time during initial hospitalization) – doxapram compared to alternative treatment for the prevention of reintubation · prevention of reintubation

The review found no eligible studies for this question.

1 finding from 1 review

Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or

5a.Moderate‐to‐severe neurodevelopmental disability or intellectual impairment after 2 years of age – doxapram compared to no treatment for the prevention of reintubation · prevention of reintubation

The review found no eligible studies for this question.

1 finding from 1 review

Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or

5b. Moderate‐to‐severe neurodevelopmental disability or intellectual impairment after 2 years of age – doxapram compared to alternative treatment for the prevention of reintubation · prevention of reintubation

The review found no eligible studies for this question.

1 finding from 1 review

Dental examinations at three-month intervals and preventive treatments vs usual care

MRONJ (incidence proportion) · Men with metastatic prostate cancer receiving intravenous zoledronic acid (at risk of MRONJ)

It is very uncertain whether dental examinations at three-month intervals and preventive treatments changes MRONJ (incidence proportion) compared with standard care (very low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs artemether‐lumefantrine (AL)

Total failure: day 28 (PCR‐adjusted) · adults and children with uncomplicated P falciparum malaria

Pyronaridine‐artesunate (PY‐AS) showed no clear difference in total failure: day 28 (PCR‐adjusted) compared with artemether‐lumefantrine (AL) (low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs artemether‐lumefantrine (AL)

Total failure: day 42 (PCR‐adjusted) · adults and children with uncomplicated P falciparum malaria

Pyronaridine‐artesunate (PY‐AS) showed no clear difference in total failure: day 42 (PCR‐adjusted) compared with artemether‐lumefantrine (AL) (low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs artemether‐lumefantrine (AL)

Total failure: day 28 (unadjusted) · adults and children with uncomplicated P falciparum malaria

Pyronaridine‐artesunate (PY‐AS) may leads to lower total failure: day 28 (unadjusted) compared with artemether‐lumefantrine (AL) (low certainty).

2 findings from 1 review