Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,509 questions · 2,666 findings · 288 reviews

No studies found 743 · 27.9%GRADE not reported 327 · 12.3%Very low 775 · 29.1%Low 484 · 18.2%Moderate 279 · 10.5%High 58 · 2.2%

Imiquimod vs cidofovir

Response to treatment at 6 months ‐ overall response · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod showed no clear difference in response to treatment at 6 months ‐ overall response compared with cidofovir (moderate certainty).

1 finding from 1 review

SUMMARY OF FINDINGS FOR DECOMPRESSION vs fusion

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients with lumbar stenosis

It is very uncertain whether SUMMARY OF FINDINGS FOR DECOMPRESSION changes pain Long‐term (≥ 12 months) Pain scores converted to 0 to 100 scale… compared with FUSION (very low certainty).

1 finding from 1 review

SUMMARY OF FINDINGS FOR FUSION vs INTERSPINOUS SPACERS

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients with lumbar stenosis

SUMMARY OF FINDINGS FOR FUSION showed no clear difference in pain Long‐term (≥ 12 months) Pain scores converted to 0 to 100 scale… compared with INTERSPINOUS SPACERS (low certainty).

1 finding from 1 review

SUMMARY OF FINDINGS FOR FUSION vs INTERSPINOUS SPACERS

Disability Long‐term (≥ 12 months) Disability scores converted to 0 to 100 scale to allow for comparison of different disability scales (RMDQ, ODI, JOA) · patients with lumbar stenosis

SUMMARY OF FINDINGS FOR FUSION may leads to higher disability Long‐term (≥ 12 months) Disability scores converted to 0… compared with INTERSPINOUS SPACERS (low certainty).

1 finding from 1 review

SUMMARY OF FINDINGS FOR FUSION vs INTERSPINOUS SPACERS

Total operative and perioperative blood loss (mL) ( · patients with lumbar stenosis

SUMMARY OF FINDINGS FOR FUSION probably leads to higher blood loss Amount of perioperative blood loss reported in mL compared with INTERSPINOUS SPACERS (moderate certainty).

1 finding from 1 review

SUMMARY OF FINDINGS FOR DECOMPRESSION vs fusion

Disability Long‐term (≥ 12 months) Disability scores converted to 0 to 100 scale to allow for comparison of different disability scales (RMDQ, ODI, JOA) · patients with lumbar stenosis

It is very uncertain whether SUMMARY OF FINDINGS FOR DECOMPRESSION changes disability Long‐term (≥ 12 months) Disability scores converted to 0… compared with FUSION (very low certainty).

1 finding from 1 review

SUMMARY OF FINDINGS FOR DECOMPRESSION vs INTERSPINOUS SPACERS

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients with lumbar stenosis

SUMMARY OF FINDINGS FOR DECOMPRESSION showed no clear difference in pain Long‐term (≥ 12 months) Pain scores converted to 0 to 100 scale… compared with INTERSPINOUS SPACERS (moderate certainty).

1 finding from 1 review

SUMMARY OF FINDINGS FOR DECOMPRESSION vs INTERSPINOUS SPACERS

Disability Long‐term (≥ 12 months) Disability scores converted to 0 to 100 scale to allow for comparison of different disability scales (RMDQ, ODI, JOA) · patients with lumbar stenosis

SUMMARY OF FINDINGS FOR DECOMPRESSION showed no clear difference in disability Long‐term (≥ 12 months) Disability scores converted to 0… compared with INTERSPINOUS SPACERS (low certainty).

1 finding from 1 review

Intramedullary fixation vs open reduction and internal fixation with plate

Function (overall) Various tools · adults (aged ≥ 16 years) with acute middle third clavicle fractures

Intramedullary fixation may leads to higher function or disability (overall) Various tools (Constant score and… compared with open reduction and internal fixation with plate (low certainty).

1 finding from 1 review

Intramedullary fixation vs open reduction and internal fixation with plate

Pain ‐ using the section of Constant score Scale from 0 to 15; with 15 being the best positive score · adults (aged ≥ 16 years) with acute middle third clavicle fractures

It is very uncertain whether intramedullary fixation changes pain ‐ using the section of Constant score Scale from 0 to 15; with… compared with open reduction and internal fixation with plate (very low certainty).

1 finding from 1 review