Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,532 questions · 2,642 findings · 483 reviews · Headline outcomes only

No studies found 534 · 20.2%GRADE not reported 82 · 3.1%Very low 641 · 24.3%Low 807 · 30.5%Moderate 472 · 17.9%High 106 · 4%

Physical and cognitive therapy vs usual care

In‐hospital mortality at 30 days or at the longest · critically ill patients 18 years or older treated for respiratory failure or septic or both, cardiogenic or haemorrhagic shock who resided…

It is very uncertain whether physical and cognitive therapy changes in‐hospital mortality at 30 days or at the longest compared with standard care (very low certainty).

1 finding from 1 review

Early intervention (mobilization or active exercise) vs usual care

Physical function ‐ return to independent functional status at hospital discharge Defined as ability to perform 6 ADLs (bathing, dressing, eating, grooming, transferring from bed to chair, using the toilet) and walk independently, · critically ill, mechanically ventilated adults

Early intervention (mobilization or active exercise) may leads to higher physical function ‐ return to independent functional status at… compared with usual care (low certainty).

1 finding from 1 review

Early intervention (mobilization or active exercise) vs usual care

Physical function · critically ill, mechanically ventilated adults
3 findings from 1 review

Early intervention (mobilization or active exercise) vs usual care

Physical performance · critically ill, mechanically ventilated adults
4 findings from 1 review
Show 1 more finding

Early intervention (mobilization or active exercise) vs usual care

Adverse events Proportion of participants with one or more events, or proportion of intervention sessions where an event occurred (falls, accidental dislodgement of attachments, haemodynamic instability, oxygen desaturation or any other adverse ev... · critically ill, mechanically ventilated adults
1 finding from 1 review

Enteral vs parenteral nutrition

All‐cause mortality · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

Enteral showed no clear difference in mortality compared with parenteral nutrition (low certainty).

1 finding from 1 review

Enteral vs enteral and parenteral nutrition

Ventilator‐free days up to day 28 · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

The review found no eligible studies for this question.

1 finding from 1 review

Enteral vs enteral and parenteral nutrition

Adverse events: aspiration (as reported by study authors at end of study · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

The review found no eligible studies for this question.

1 finding from 1 review

Enteral vs enteral and parenteral nutrition

Adverse events: sepsis (as reported by study authors at end of study · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

The review found no eligible studies for this question.

1 finding from 1 review

Enteral vs enteral and parenteral nutrition

Adverse events ‐ pneumonia · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

It is very uncertain whether enteral changes adverse events: pneumonia (as reported by study authors at end of… compared with enteral and parenteral nutrition (very low certainty).

1 finding from 1 review

Enteral vs enteral and parenteral nutrition

Adverse events: Vomiting · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

The review found no eligible studies for this question.

1 finding from 1 review

Enteral vs parenteral nutrition

Number of ICU‐free days up to day 28 · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

The review found no eligible studies for this question.

1 finding from 1 review

Enteral vs parenteral nutrition

Adverse events: aspiration (as reported by study authors at end of study · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

It is very uncertain whether enteral changes adverse events: aspiration (as reported by study authors at end of… compared with parenteral nutrition (very low certainty).

1 finding from 1 review

Enteral vs parenteral nutrition

Adverse events: sepsis (as reported by study authors at end of study · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

Enteral may leads to lower adverse events: sepsis (as reported by study authors at end of study compared with parenteral nutrition (low certainty).

1 finding from 1 review

Enteral vs parenteral nutrition

Adverse events ‐ pneumonia · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

Enteral showed no clear difference in adverse events: pneumonia (as reported by study authors at end of… compared with parenteral nutrition (low certainty).

1 finding from 1 review

Enteral vs parenteral nutrition

Adverse events: Vomiting · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

It is very uncertain whether enteral changes adverse events: vomiting (as reported by study authors at end of study compared with parenteral nutrition (very low certainty).

1 finding from 1 review