Findings

What do systematic reviews say?

4,783 questions · 10,022 findings · 882 reviews

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No studies found 2,100 · 21%GRADE not reported 1,013 · 10.1%Very low 2,237 · 22.3%Low 2,514 · 25.1%Moderate 1,709 · 17.1%High 449 · 4.5%

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Antibiotics vs no intervention

Minor adverse events · newborns with congenital syphilis

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic treatment for newborns with congenital syphilis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Prebiotic vs no prebiotics

Treatment with phototherapy · Neonates, including term neonates (gestational age ≥ 37 weeks), late preterm neonates (35 to 37 weeks' gestation) and preterm neonates (<…

Feeding supplementation with prebiotics may leads to lower treatment with phototherapy compared with no prebiotics (low certainty).

1 finding from 1 review

Prebiotics for the prevention of hyperbilirubinaemia in neonates 2019 · Cochrane Headline outcomes only
RR 0.75 [0.58, 0.97]
1 study · 50 participants
Low

Prebiotic vs no prebiotics

Duration of phototherapy (days) · Neonates, including term neonates (gestational age ≥ 37 weeks), late preterm neonates (35 to 37 weeks' gestation) and preterm neonates (<…

1 finding from 1 review

Prebiotics for the prevention of hyperbilirubinaemia in neonates 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Low

Dextrans vs crystalloid

Renal replacement therapy

The review found no eligible studies for this question.

1 finding from 1 review

Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Gelatins vs crystalloid

Renal replacement therapy

The review found no eligible studies for this question.

1 finding from 1 review

Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Albumin and fresh frozen plasma vs crystalloid

Renal replacement therapy

Albumin and fresh frozen plasma showed no clear difference in renal replacement therapy compared with crystalloid (low certainty).

1 finding from 1 review

Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
RR 1.11 [0.96, 1.27]
2 studies · 3028 participants
Low

Starches vs crystalloid

Renal replacement therapy

Starches probably leads to higher renal replacement therapy compared with crystalloid (moderate certainty).

1 finding from 1 review

Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
RR 1.3 [1.14, 1.48]
9 studies · 8527 participants
Moderate

HFNC vs standard oxygen therapy

Length of hospital stay · infants with bronchiolitis

1 finding from 1 review

High‐flow nasal cannula therapy for infants with bronchiolitis 2024 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 1951 participants
Low

HFNC vs standard oxygen therapy

Adverse events · infants with bronchiolitis

Summary of findings table ‐ High‐flow nasal cannula showed no clear difference in adverse events compared with standard oxygen therapy (low‐flow) (low certainty).

1 finding from 1 review

High‐flow nasal cannula therapy for infants with bronchiolitis 2024 · Cochrane Headline outcomes only
RR 1.2 [0.38, 3.74]
4 studies · 1789 participants
Low

HFNC vs standard oxygen therapy

Change in respiratory rate at 20 minutes · infants with bronchiolitis

1 finding from 1 review

High‐flow nasal cannula therapy for infants with bronchiolitis 2024 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 692 participants
Low

HFNC vs standard oxygen therapy

Change** in heart rate (beats/min) · infants with bronchiolitis

1 finding from 1 review

High‐flow nasal cannula therapy for infants with bronchiolitis 2024 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 692 participants
Moderate

HFNC vs standard oxygen therapy

Need for treatment escalation · infants with bronchiolitis

Summary of findings table ‐ High‐flow nasal cannula probably leads to lower need for treatment escalation compared with standard oxygen therapy (low‐flow) (moderate certainty).

1 finding from 1 review

High‐flow nasal cannula therapy for infants with bronchiolitis 2024 · Cochrane Headline outcomes only
RR 0.55 [0.39, 0.79]
8 studies · 2215 participants
Moderate

Intervention not reported

All‐cause mortality at 31 to 100 days · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

It is very uncertain whether the intervention changes all‐cause mortality at 31 to 100 days (very low certainty).

1 finding from 1 review

Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated… 2024 · Cochrane Headline outcomes only
RR 1 [0.27, 3.7]
3 studies · 451 participants
Very low

Intervention not reported

Number of participants with any bleeding ‐ not reported · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

The review found no eligible studies for this question.

1 finding from 1 review

Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated… 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Number of participants with clinically significant bleeding · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

1 finding from 1 review

Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated… 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 84 participants
Very low

Intervention not reported

Serious infections ‐ not reported · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

The review found no eligible studies for this question.

1 finding from 1 review

Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated… 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Length of hospital admission ‐ not reported · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

The review found no eligible studies for this question.

1 finding from 1 review

Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated… 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Hospital readmission rate ‐ not reported · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

The review found no eligible studies for this question.

1 finding from 1 review

Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated… 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Quality of life (0 to 3 months) · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

1 finding from 1 review

Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated… 2024 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 431 participants
Very low

Intervention not reported

Number of participants with any bleeding (0 to 3 months) · Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem…

The intervention showed no clear difference in number of participants with any bleeding (0 to 3 months) (low certainty).

1 finding from 1 review

Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated… 2024 · Cochrane Headline outcomes only
RR 0.91 [0.78, 1.06]
3 studies · 448 participants
Low