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Evidence found and GRADE certainty

2,543 questions · 2,589 findings · 168 reviews · Schizophrenia

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No studies found 601 · 23.2%GRADE not reported 446 · 17.2%Very low 721 · 27.8%Low 505 · 19.5%Moderate 274 · 10.6%High 42 · 1.6%

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Sedation/tranquillisation: Not sedated ‐ at four hours · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE showed no clear difference in sedation/tranquillisation: Not sedated ‐ at four hours compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE (HIGH DOSE) vs ZUCLOPENTHIXOL ACETATE (LOW DOSE)

Mental state: 2. Not improved (BPRS, < 30% decrease in BPRS score) · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE (HIGH DOSE) showed no clear difference in mental state: 2. Not improved (BPRS, < 30% decrease in BPRS score) compared with ZUCLOPENTHIXOL ACETATE (LOW DOSE) (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE (HIGH DOSE) vs ZUCLOPENTHIXOL ACETATE (LOW DOSE)

Adverse effects/events ‐ extrapyramidal symptoms ‐ medium term Number of instances of extrapyramidal symptoms · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE (HIGH DOSE) showed no clear difference in adverse effects: 1. Extrapyramidal side effects (TESS) compared with ZUCLOPENTHIXOL ACETATE (LOW DOSE) (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Global state: 1. Requiring supplementary medication ‐ antipsychotics · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE showed no clear difference in global state: 1. Requiring supplementary medication ‐ antipsychotics compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Global state: 2. Requiring 3 or more injections ‐ over 7 days · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE may leads to lower global state: 2. Requiring 3 or more injections ‐ over 7 days compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Clinical response: no clinically significant response in mental state · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE showed no clear difference in mental state: 1. No important improvement compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Adverse effects: Specific ‐ dystonia during 24 hours · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE showed no clear difference in adverse effects: Movement disorders ‐ dystonia (spasmodic postural… compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE (HIGH DOSE) vs ZUCLOPENTHIXOL ACETATE (LOW DOSE)

Mental state: 1. Not markedly improved (BPRS, < 60% decrease in BPRS score) · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE (HIGH DOSE) showed no clear difference in mental state: 1. Not markedly improved (BPRS, < 60% decrease in BPRS… compared with ZUCLOPENTHIXOL ACETATE (LOW DOSE) (low certainty).

1 finding from 1 review