Adverse events (participants with adverse events or withdrawals due to adverse events) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
1 finding from 1 review
SoF 1 (Adverse effects): Only 1 study reported that 1 participant in the treatment group experienced a myocardial infarction during the study period. 1 study reported no adverse effects. The remaining 2 studies did not…
2 studies · 294 participants
Low
All‐cause mortality · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment
It is very uncertain whether band ligation changes all‐cause mortality compared with sham or no intervention (very low certainty).
1 finding from 1 review
Serious adverse events Idiopathic thrombocytopaenic purpura · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment
It is very uncertain whether band ligation changes serious adverse events Idiopathic thrombocytopaenic purpura compared with sham or no intervention (very low certainty).
1 finding from 1 review
Health‐related quality of life · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Oesophageal variceal bleeding · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment
It is very uncertain whether band ligation changes oesophageal variceal bleeding compared with sham or no intervention (very low certainty).
1 finding from 1 review
Adverse events considered non‐serious · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Combined outcome of proportion of participants with major or critical monitoring findings · clinical trials in all fields of health care
Risk‐based showed no clear difference in combined outcome of proportion of participants with major or… compared with extensive on‐site monitoring (moderate certainty).
1 finding from 1 review
Impact of the monitoring strategy on participant recruitment · clinical trials in all fields of health care
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Impact of the monitoring strategy on · clinical trials in all fields of health care
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Resource use · clinical trials in all fields of health care
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Endothelial function · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
Periodontal treatment (subgingival SRP with or without other… showed no clear difference in endothelial function (forearm blood flow) compared with no treatment (no periodontal treatment); GRADE not reported.
1 finding from 1 review
Plasma level of IL-6 (pg/mL) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
Periodontal treatment (subgingival SRP with or without other… showed no clear difference in plasma level of IL-6 (pg/mL) compared with no treatment (no periodontal treatment); GRADE not reported.
3 findings from 1 review
Percentage of bleeding on probing (BOP) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
Periodontal treatment (subgingival SRP with or without other… led to lower bleeding on probing (BOP) compared with no treatment (no periodontal treatment); GRADE not reported.
1 finding from 1 review
Heart rate · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
Periodontal treatment (subgingival SRP with or without other… showed no clear difference in heart rate compared with no treatment (no periodontal treatment); GRADE not reported.
1 finding from 1 review
Intervention not reported
Change in the visual field (short term) · participants with glaucoma or intraocular hypertension
1 finding from 1 review
Intervention not reported
Reduction in IOP (short term) · participants with glaucoma or intraocular hypertension
1 finding from 1 review
Intervention not reported
Change in visual acuity (short term) · participants with glaucoma or intraocular hypertension
1 finding from 1 review
Intervention not reported
Progression of optic disc damage or nerve fiber layer loss (short term) · participants with glaucoma or intraocular hypertension
1 finding from 1 review
Intervention not reported
Adverse events (short term) · participants with glaucoma or intraocular hypertension
1 finding from 1 review
Variation in the decrease in 24‐hour ambulatory hourly SBP (at 3 to 12 weeks) · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
no estimate extracted
121 participants
Very low