Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,973 questions · 3,072 findings · 410 reviews · Headline outcomes only

No studies found 559 · 18.2%GRADE not reported 143 · 4.7%Very low 654 · 21.3%Low 833 · 27.1%Moderate 683 · 22.2%High 200 · 6.5%

Structural and community‐level interventions for increasing condom use vs usual care

HIV incidence (observational studies) · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in HIV incidence (person/years) compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

HIV prevalence · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in HIV prevalence compared with standard care (low certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Herpes Simplex Virus 2 (HSV‐2) incidence (person/years) · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in herpes Simplex Virus 2 (HSV‐2) incidence (person/years) compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

HSV‐2 prevalence · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in HSV‐2 prevalence compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Two or more sexual partners in last year · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in two or more sexual partners in last year compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Use of birth control methods (condom use at last sex) · low and high‐risk populations

Structural and community‐level interventions for increasing condom use probably leads to higher use of condom during last sexual intercourse compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Knowledge: condom can prevent STIs · low and high‐risk populations

Structural and community‐level interventions for increasing condom use probably leads to higher knowledge: condom can prevent STIs compared with standard care (moderate certainty).

1 finding from 1 review

Vitamin D vs placebo or no intervention

Cancer occurrence · healthy participants or recruited among the general population; individuals diagnosed with a specific disease in a stable phase or with…

Vitamin D showed no clear difference in cancer occurrence compared with placebo or no intervention (moderate certainty).

1 finding from 1 review

Vitamin D vs placebo or no intervention

Cancer occurrence in trials using vitamin D₃ (cholecalciferol) · healthy participants or recruited among the general population; individuals diagnosed with a specific disease in a stable phase or with…

Vitamin D showed no clear difference in cancer occurrence in trials using vitamin D₃ (cholecalciferol) compared with placebo or no intervention (moderate certainty).

1 finding from 1 review

Vitamin D vs placebo or no intervention

Cancer mortality in trials using vitamin D3 (cholecalciferol) ( · healthy participants or recruited among the general population; individuals diagnosed with a specific disease in a stable phase or with…

Vitamin D may leads to lower cancer mortality in trials using vitamin D₃(cholecalciferol) compared with placebo or no intervention (low certainty).

1 finding from 1 review

Vitamin D vs placebo or no intervention

Adverse events ‐ Nephrolithiasis in trials using vitamin D3 combined with calcium · healthy participants or recruited among the general population; individuals diagnosed with a specific disease in a stable phase or with…

Vitamin D may leads to higher adverse events: nephrolithiasis in trials using vitamin… compared with placebo or no intervention (low certainty).

1 finding from 1 review