Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,327 questions · 2,494 findings · 87 reviews · Oral Health

No studies found 450 · 18%GRADE not reported 1,487 · 59.6%Very low 385 · 15.4%Low 121 · 4.9%Moderate 50 · 2%High 1 · 0%

Bio-Oss (anorganic bovine bone) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Augmentation (prosthesis/implant) failure · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Bio-Oss (anorganic bovine bone) led to lower augmentation (prosthesis/implant) failure compared with bio-Oss + resorbable barrier; GRADE not reported.

1 finding from 1 review

Bio-Oss (anorganic bovine bone) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Poor aesthetics measured by dentist (3 years) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Bio-Oss (anorganic bovine bone) led to lower poor aesthetics measured by dentist (3 years) compared with bio-Oss + resorbable barrier; GRADE not reported.

1 finding from 1 review

Oral diclofenac sodium (NSAID) vs placebo

Daily pain (not improved) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral diclofenac sodium (NSAID) showed no clear difference in daily pain (not improved) compared with placebo; GRADE not reported.

1 finding from 1 review

Mechanical debridement plus topical minocycline vs Mechanical debridement plus chlorhexidine gel

Soreness in the gums · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement plus topical minocycline showed no clear difference in soreness in the gums compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.

1 finding from 1 review

Two-stage sinus lift + buccal onlay iliac grafts WITH platelet-rich plasma (PRP) vs Same grafts WITHOUT PRP (split-mouth)

Implant/prosthesis failure and complications · Patients with resorbed maxillae (incl. atrophic sinuses) needing implants
1 finding from 1 review

Any denture cleansing method (mechanical or chemical) vs Another therapy, placebo, or no treatment

Costs · Adults (over 18) wearing complete dentures (CD) or removable partial dentures (RPD)

The review found no eligible studies for this question.

1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    Noticeable absence of reports about costs of materials associated with denture cleansing methods; no included study assessed costs (Discussion; Implications for research).
    0 studies
    No studies found

Vertical distraction osteogenesis vs Autogenous onlay bone graft (mandibular ramus)

Augmentation procedure (partial) failure · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical distraction osteogenesis showed no clear difference in augmentation procedure (partial) failure compared with autogenous onlay bone graft (mandibular ramus); GRADE not reported.

1 finding from 1 review

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Overall survival · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Inlay autogenous bone graft (iliac crest) vs Inlay bone substitute (Bio-Oss block)

Perimplant bone loss · Patients with atrophic posterior mandibles (5 to 7 mm above the mandibular canal) needing implants

Inlay autogenous bone graft (iliac crest) showed no clear difference in perimplant bone loss compared with inlay bone substitute (Bio-Oss block); GRADE not reported.

1 finding from 1 review

Inlay autogenous bone graft (iliac crest) vs Inlay bone substitute (Bio-Oss block)

Vertical bone gain · Patients with atrophic posterior mandibles (5 to 7 mm above the mandibular canal) needing implants

Inlay autogenous bone graft (iliac crest) showed no clear difference in vertical bone gain compared with inlay bone substitute (Bio-Oss block); GRADE not reported.

1 finding from 1 review

Calcitonin (salmon calcitonin nasal spray 200 IU/day) vs placebo

Increase in volume of more than 10% compared to the pretreatment measurement · Patients with histologically confirmed CGCG in one or both jaws and normal serum calcium and parathyroid hormone (PTH) levels

Calcitonin (salmon calcitonin nasal spray 200 IU/day) showed no clear difference in increase in volume of more than 10% compared to the pretreatment… compared with placebo; GRADE not reported.

1 finding from 1 review

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Disease-free survival · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Resectability · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Quality of life · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Any denture cleansing method (mechanical or chemical) vs Another method, sham/placebo, or no treatment

Outcome not reported · Adults (over 18) wearing complete dentures (CD) or removable partial dentures (RPD)
1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    Although six RCTs were included in this review, the wide range of different interventions and outcome variables did not permit pooling of data in a meta-analysis. Isolated reports indicated that chemicals and brushing…
    6 studies
    GRADE not reported

Inlay autogenous bone graft (iliac crest) vs Autogenous onlay bone graft (iliac crest)

Graft failure · Patients with deficient posterior mandibles (4.5 to 10 mm above the mandibular canal) needing implants

Autogenous inlay bone graft (iliac crest) showed no clear difference in graft failure compared with autogenous onlay bone graft (iliac crest); GRADE not reported.

1 finding from 1 review

Calcitonin (salmon calcitonin nasal spray 200 IU/day) vs placebo

Adverse events · Patients with histologically confirmed CGCG in one or both jaws and normal serum calcium and parathyroid hormone (PTH) levels
1 finding from 1 review
  • Adverse events were not described separately for each group. Trialists reported that adverse events were in most patients minimal and consisted of nausea, flushes and some dizziness. One patient had diarrhoea which…
    1 study · 14 participants
    GRADE not reported

1-stage (non-submerged) implant placement vs 2-stage (submerged) implant placement

Aesthetics evaluated by dentists (soft tissue recession) · People with dental implants

1-stage (non-submerged) implant placement showed no clear difference in aesthetics evaluated by dentists (soft tissue recession) compared with 2-stage (submerged) implant placement; GRADE not reported.

1 finding from 1 review

Inlay autogenous bone graft (iliac crest) vs Inlay bone substitute (Bio-Oss block)

Patient preference · Patients with atrophic posterior mandibles (5 to 7 mm above the mandibular canal) needing implants

Inlay autogenous bone graft (iliac crest) led to lower patient preference compared with inlay bone substitute (Bio-Oss block); GRADE not reported.

1 finding from 1 review

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Experienced the operation negatively · Patients with atrophic (resorbed) mandibles needing implants

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… showed no clear difference in experienced the operation negatively compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

1 finding from 1 review