Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,783 questions · 10,022 findings · 882 reviews

No studies found 2,100 · 21%GRADE not reported 1,013 · 10.1%Very low 2,237 · 22.3%Low 2,514 · 25.1%Moderate 1,709 · 17.1%High 449 · 4.5%

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Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Fever · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar…

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes fever (6th-7th day) compared with placebo (very low certainty).

1 finding from 1 review

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs Placebo

Outcome not reported · Patients undergoing tooth extraction for severe dental caries or periodontal disease in general dental practice (non-third-molar / decayed…

The review found no eligible studies for this question.

1 finding from 1 review
  • No studies in general dental practice for removal of decayed teeth. PUB3 added one routine intra-alveolar extraction trial and one complex oral surgery trial (2 of 23 non-third-molar), but the single intra-alveolar…
    0 studies
    No studies found

Group B cognitive behavioural therapy: cognitive behavioural therapy (specific preventive intervention) + needs‐based intervention + risperidone vs needs‐based intervention

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes prodromal symptoms: transition to psychosis Endpoint data (events)… compared with needs‐based intervention (very low certainty).

1 finding from 1 review

Group B cognitive behavioural therapy: cognitive behavioural therapy (specific preventive intervention) + needs‐based intervention + risperidone vs needs‐based intervention

Satisfaction with treatment: 1. Leaving the study early ‐ long term · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes satisfaction with treatment: leaving the study early (events)… compared with needs‐based intervention (very low certainty).

1 finding from 1 review

Hospital‐only intervention vs intervention that continues after hospital discharge

Pharmacotherapy + behavioural support vs neither · smoking cessation in hospitalised patients

Hospital‐only intervention leads to higher pharmacotherapy + behavioural support vs neither compared with intervention that continues after hospital discharge (high certainty).

1 finding from 1 review

Prophylactic corticosteroids vs placebo or no corticosteroids

Infectious complications · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with cardiopulmonary bypass

Prophylactic corticosteroids may leads to lower infectious complications (as defined by study authors, including… compared with placebo or no corticosteroids (low certainty).

1 finding from 1 review

Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening vs visual assessment

Readmission for phototherapy for hyperbilirubinemia · newborns for hyperbilirubinemia

Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening probably leads to lower readmission for phototherapy for hyperbilirubinemia compared with visual assessment (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening vs visual assessment

Phototherapy before hospital discharge · newborns for hyperbilirubinemia

Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening probably leads to higher phototherapy before hospital discharge compared with visual assessment (moderate certainty).

1 finding from 1 review

Summary of findings: Any alternative model of care vs usual care

Adherence to clinical guideline‐recommended care: proportion of residents with adequate antidepressant therapy at longest · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)

It is very uncertain whether summary of findings: Any alternative model of care changes adherence to clinical guideline‐recommended care: proportion of… compared with usual care (very low certainty).

1 finding from 1 review

Intervention not reported

Bupropion therapy plus behavioral intervention vs behavioral intervention alone (continuous waterpipe smoking abstinence, defined as an expired CO of 9 ppm or less at the 6‐month postintervention · people who use waterpipe

It is very uncertain whether the intervention changes bupropion therapy plus behavioral intervention vs behavioral… (very low certainty).

1 finding from 1 review

Intervention not reported

Bupropion therapy plus behavioral support versus self‐help (continuous waterpipe smoking abstinence, defined as an expired CO of 9 ppm or less at the 6‐month postintervention · people who use waterpipe

It is very uncertain whether the intervention changes bupropion therapy plus behavioral support versus self‐help… (very low certainty).

1 finding from 1 review

Dextrose gel vs placebo

Receipt of treatment for hypoglycaemia during initial hospital stay (investigator‐defined, any treatment ‐ oral dextrose gel, intravenous dextrose, or other drug therapy) during initial hospital stay (yes/no) · newborn infants at risk of neonatal hypoglycaemia

Dextrose gel showed no clear difference in receipt of treatment for hypoglycaemia during initial hospital stay… compared with placebo (moderate certainty).

1 finding from 1 review

Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or

side‐effects ‐ side‐effects causing abandon · treatment of apnea
3 findings from 1 review