Gap finder
Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,518 questions in 135 reviews · Infectious Diseases
current versionsNo studies 135 · 8.9%Ungraded 150 · 9.9%Very low 350 · 23.1%Low 420 · 27.7%Moderate 321 · 21.1%High 142 · 9.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intervention NR Serious adverse events · adults and children with confirmed clinical and parasitological P vivax malaria Primaquine alternative dosing schedules for preventing malaria relapse in people with Plasmodium vivax (2020) · Cochrane | no estimate extracted | 5 studies · 1427 participants | Ungraded |
Intervention NR Adverse events that result in the discontinuation of treatment · adults and children with confirmed clinical and parasitological P vivax malaria Primaquine alternative dosing schedules for preventing malaria relapse in people with Plasmodium vivax (2020) · Cochrane | RR 1.04 [0.15, 7.38] | 5 studies · 1427 participants | Very low |
Intervention NR Anaemia or change in haemoglobin status · adults and children with confirmed clinical and parasitological P vivax malaria Primaquine alternative dosing schedules for preventing malaria relapse in people with Plasmodium vivax (2020) · Cochrane | RR 3 [0.12, 72.91] | 1 study · 240 participants | Very low |
Intervention NR Recurrence of P vivax parasitaemia · adults and children with confirmed clinical and parasitological P vivax malaria Primaquine alternative dosing schedules for preventing malaria relapse in people with Plasmodium vivax (2020) · Cochrane | RR 0.84 [0.49, 1.43] | 2 studies · 677 participants | Low |
Intervention NR Serious adverse events · adults and children with confirmed clinical and parasitological P vivax malaria Primaquine alternative dosing schedules for preventing malaria relapse in people with Plasmodium vivax (2020) · Cochrane | no estimate extracted | 1 study · 778 participants | Ungraded |
Intervention NR Adverse events that result in the discontinuation of treatment · adults and children with confirmed clinical and parasitological P vivax malaria Primaquine alternative dosing schedules for preventing malaria relapse in people with Plasmodium vivax (2020) · Cochrane | RR 4.19 [0.9, 19.6] | 1 study · 778 participants | Very low |
Intervention NR Recurrence of P vivax malaria · adults and children with confirmed clinical and parasitological P vivax malaria Primaquine alternative dosing schedules for preventing malaria relapse in people with Plasmodium vivax (2020) · Cochrane | RR 3.18 [0.37, 27.6] | 1 study · 122 participants | Very low |
Intervention NR Serious adverse events · adults and children with confirmed clinical and parasitological P vivax malaria Primaquine alternative dosing schedules for preventing malaria relapse in people with Plasmodium vivax (2020) · Cochrane | no estimate extracted | 1 study · 129 participants | Ungraded |
Intervention NR True positives (patients with P vivax malaria) · people presenting with symptoms of uncomplicated malaria Rapid diagnostic tests for Plasmodium vivax malaria in endemic countries (2020) · Cochrane | no estimate extracted | NR | Moderate |
Intervention NR False negatives (patients incorrectly classified as not having P vivax malaria) · people presenting with symptoms of uncomplicated malaria Rapid diagnostic tests for Plasmodium vivax malaria in endemic countries (2020) · Cochrane | no estimate extracted | NR | Moderate |
Intervention NR True negatives (patients without P vivax malaria) · people presenting with symptoms of uncomplicated malaria Rapid diagnostic tests for Plasmodium vivax malaria in endemic countries (2020) · Cochrane | no estimate extracted | NR | Moderate |
Intervention NR False positives(patients incorrectly classified as having P vivax malaria) · people presenting with symptoms of uncomplicated malaria Rapid diagnostic tests for Plasmodium vivax malaria in endemic countries (2020) · Cochrane | no estimate extracted | NR | Moderate |
Intervention NR Test result · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 0 participants | Ungraded |
Intervention NR False positives (participants incorrectly classified as having pneumonic plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 290 participants | Very low |
Intervention NR Test result · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 0 participants | Ungraded |
Intervention NR True positives (participants correctly classified as having bubonic plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 1 participants | Low |
Intervention NR False negatives (participants incorrectly classified as not having bubonic plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 0 participants | Low |
Intervention NR True negatives (participants correctly classified as not having bubonic plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 669 participants | Very low |
Intervention NR False positives (participants incorrectly classified as having bubonic plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 330 participants | Very low |
Intervention NR Test result · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 0 participants | Ungraded |
Intervention NR True positives (participants correctly classified as having bubonic plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 1 participants | Very low |
Intervention NR False negatives (participants incorrectly classified as not having bubonic plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 0 participants | Very low |
Intervention NR True negatives (participants correctly classified as not having bubonic plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 929 participants | Very low |
Intervention NR True positives (participants correctly classified as having plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 1 participants | Very low |
Intervention NR False positives (participants incorrectly classified as having bubonic plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 70 participants | Very low |
Intervention NR False negatives (participants incorrectly classified as not having plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 0 participants | Very low |
Intervention NR True negatives (participants correctly classified as not having plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 699 participants | Very low |
Intervention NR False positives (participants incorrectly classified as having plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 300 participants | Very low |
Intervention NR Test result · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 0 participants | Ungraded |
Intervention NR True positives (participants correctly classified as having pneumonic plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 1 participants | Very low |
Intervention NR False negatives (participants incorrectly classified as not having pneumonic plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 0 participants | Very low |
Intervention NR True negatives (participants correctly classified as not having pneumonic plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults… Rapid diagnostic tests for plague (2020) · Cochrane | no estimate extracted | 709 participants | Very low |
Induction: liposomal amphotericin vs amphotericin deoxycholate Clinical success · adults with HIV and progressive disseminated histoplasmosis Treating progressive disseminated histoplasmosis in people living with HIV (2020) · Cochrane | RR 1.46 [1.01, 2.11] | 1 study · 80 participants | Low |
Induction: liposomal amphotericin vs amphotericin deoxycholate Death · adults with HIV and progressive disseminated histoplasmosis Treating progressive disseminated histoplasmosis in people living with HIV (2020) · Cochrane | RR 0.15 [0.02, 1.38] | 1 study · 77 participants | Low |
Induction: liposomal amphotericin vs amphotericin deoxycholate Safety outcomes: nephrotoxicity · adults with HIV and progressive disseminated histoplasmosis Treating progressive disseminated histoplasmosis in people living with HIV (2020) · Cochrane | RR 0.25 [0.09, 0.67] | 1 study · 77 participants | High |
Induction: liposomal amphotericin vs amphotericin deoxycholate Safety outcomes: drug discontinuation · adults with HIV and progressive disseminated histoplasmosis Treating progressive disseminated histoplasmosis in people living with HIV (2020) · Cochrane | RR 0.23 [0.02, 2.38] | 1 study · 77 participants | Very low |
Hand cleaning with ash vs soap Death · people at risk of viral and bacterial infections Hand cleaning with ash for reducing the spread of viral and bacterial infections: a rapid review (2020) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Hand cleaning with ash vs water or no wash Adherence · people at risk of viral and bacterial infections Hand cleaning with ash for reducing the spread of viral and bacterial infections: a rapid review (2020) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Hand cleaning with ash vs soap Infectionsa · people at risk of viral and bacterial infections Hand cleaning with ash for reducing the spread of viral and bacterial infections: a rapid review (2020) · Cochrane | no estimate extracted | 2 studies · 1057 participants | Very low |
Hand cleaning with ash vs soap Severity of infections · people at risk of viral and bacterial infections Hand cleaning with ash for reducing the spread of viral and bacterial infections: a rapid review (2020) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Hand cleaning with ash vs soap Harms · people at risk of viral and bacterial infections Hand cleaning with ash for reducing the spread of viral and bacterial infections: a rapid review (2020) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Hand cleaning with ash vs soap Adherence · people at risk of viral and bacterial infections Hand cleaning with ash for reducing the spread of viral and bacterial infections: a rapid review (2020) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Hand cleaning with ash vs water or no wash Death · people at risk of viral and bacterial infections Hand cleaning with ash for reducing the spread of viral and bacterial infections: a rapid review (2020) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Hand cleaning with ash vs water or no wash Infectionsa · people at risk of viral and bacterial infections Hand cleaning with ash for reducing the spread of viral and bacterial infections: a rapid review (2020) · Cochrane | RR 0.5 [0.13, 1.96] | 1 study · 196 participants | Very low |
Hand cleaning with ash vs water or no wash Severity of infections · people at risk of viral and bacterial infections Hand cleaning with ash for reducing the spread of viral and bacterial infections: a rapid review (2020) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Hand cleaning with ash vs water or no wash Harms · people at risk of viral and bacterial infections Hand cleaning with ash for reducing the spread of viral and bacterial infections: a rapid review (2020) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Multiple doses of deworming drugs vs placebo Weight (kg) · public health programmes to regularly treat all children aged 16 years or less Public health deworming programmes for soil‐transmitted helminths in children living in endemic areas (2019) · Cochrane | no estimate extracted | 18 studies · 52448 participants | Very low |
A single dose of deworming drugs vs placebo Height (cm) · public health programmes to regularly treat all children aged 16 years or less Public health deworming programmes for soil‐transmitted helminths in children living in endemic areas (2019) · Cochrane | no estimate extracted | 10 studies · 2621 participants | Low |
A single dose of deworming drugs vs placebo Haemoglobin (g/dL) · public health programmes to regularly treat all children aged 16 years or less Public health deworming programmes for soil‐transmitted helminths in children living in endemic areas (2019) · Cochrane | no estimate extracted | 5 studies · 1252 participants | Moderate |
A single dose of deworming drugs vs placebo Formal tests of cognition · public health programmes to regularly treat all children aged 16 years or less Public health deworming programmes for soil‐transmitted helminths in children living in endemic areas (2019) · Cochrane | no estimate extracted | 5 studies · 1596 participants | Low |