Cochrane · systematic review · CD013459
Rapid diagnostic tests for plague
Jullien, S, Dissanayake, HA, Chaplin, M · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
20
current version
GRADE rated
16
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 4 · 20%Very low 14 · 70%Low 2 · 10%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
F1RDT against culture for all forms of plague
Population: s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults and children with suspicion of plague Index test: F1RDT from Institut Pasteur of Madagascar Reference standard: culture Study design: retrospective reports Pooled sensitivity: 1.00 (95% CI 0.82 to 1.00). Pooled specificity: 0.70 (95% CI 0.65 to 0.75)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Test result | no estimate extracted | 0 participants | Ungraded |
True positives (participants correctly classified as having plague) | no estimate extracted | 1 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
False negatives (participants incorrectly classified as not having plague) | no estimate extracted | 0 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
True negatives (participants correctly classified as not having plague) | no estimate extracted | 699 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
False positives (participants incorrectly classified as having plague) | no estimate extracted | 300 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
F1RDT against culture for pneumonic plague
Population: s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults and children with suspicion of pneumonic plague Index test: F1RDT from Institut Pasteur of Madagascar performed in sputum Reference standard: sputum culture Study design: retrospective reports Pooled sensitivity: 1.00 (95% CI 0.00 to 1.00). Pooled specificity: 0.71 (95% CI 0.59 to 0.80)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Test result | no estimate extracted | 0 participants | Ungraded |
True positives (participants correctly classified as having pneumonic plague) | no estimate extracted | 1 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
False negatives (participants incorrectly classified as not having pneumonic plague) | no estimate extracted | 0 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
True negatives (participants correctly classified as not having pneumonic plague) | no estimate extracted | 709 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
False positives (participants incorrectly classified as having pneumonic plague) | no estimate extracted | 290 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
F1RDT against culture for bubonic plague
Population: s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults and children with suspicion of bubonic plague Index test: F1RDT from Institut Pasteur of Madagascar performed in bubo aspirate Reference standard: culture from bubo aspirate Study design: retrospective reports Pooled sensitivity: 1.00 (95% CI not calculable). Pooled specificity: 0.67 (95% CI 0.65 to 0.70)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Test result | no estimate extracted | 0 participants | Ungraded |
True positives (participants correctly classified as having bubonic plague) | no estimate extracted | 1 participants | Low Downgraded: risk of bias, indirectness |
False negatives (participants incorrectly classified as not having bubonic plague) | no estimate extracted | 0 participants | Low Downgraded: risk of bias, indirectness |
True negatives (participants correctly classified as not having bubonic plague) | no estimate extracted | 669 participants | Very low Downgraded: risk of bias, indirectness |
False positives (participants incorrectly classified as having bubonic plague) | no estimate extracted | 330 participants | Very low Downgraded: risk of bias, indirectness |
F1RDT against PCR for bubonic plague
Population: s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults and children with suspicion of bubonic plague Index test: F1RDT from Institut Pasteur of Madagascar performed in bubo aspirate Reference standard: PCR (caf1) from bubo aspirate Study design: retrospective reports Pooled sensitivity: 0.95 (95% CI 0.89 to 0.99). Pooled specificity: 0.93 (95% CI 0.84 to 0.98)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Test result | no estimate extracted | 0 participants | Ungraded |
True positives (participants correctly classified as having bubonic plague) | no estimate extracted | 1 participants | Very low Downgraded: risk of bias, imprecision |
False negatives (participants incorrectly classified as not having bubonic plague) | no estimate extracted | 0 participants | Very low Downgraded: risk of bias, imprecision |
True negatives (participants correctly classified as not having bubonic plague) | no estimate extracted | 929 participants | Very low Downgraded: risk of bias, imprecision |
False positives (participants incorrectly classified as having bubonic plague) | no estimate extracted | 70 participants | Very low Downgraded: risk of bias, imprecision |