Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
It is very uncertain whether non-selective carious tissue removal and conventional restoration (CR) changes failure of therapy compared with selective carious tissue removal (selective excavation, SE) (very low certainty).
3 findings from 1 review
Specificity for detection of enamel caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Harms (toxicity and postoperative sensitivity) · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6 to 12 years)
1 finding from 1 review
SoF (Harms, follow-up 2 weeks to 7 years): See comments; 3 studies; certainty very low (⊕⊝⊝⊝). Comments: data were reported for physical development, neurological and psychological effects, neurobehavioural and…
3 studies
Very low
Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
3 findings from 1 review
Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
COE with blood/salivary (biomarker) analysis vs Reference standard: examination and clinical evaluation by a physician/clinician with specialist knowledge or training (long-term follow-up accepted for those screened negative)
Outcome not reported · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…
The review found no eligible studies for this question.
1 finding from 1 review
Specificity for detection of oral cavity cancer/OPMD · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…
1 finding from 1 review
Summary of findings 4 (no pooled analysis): specificity 0.99 (95% CI 0.99 to 1.00), 1.00 (95% CI 0.91 to 1.00), and 0.72 (95% CI 0.63 to 0.80) across the 3 studies. Certainty VERY LOW.
3 studies · 3600 participants
Very low
Sensitivity · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or extracted teeth of…
2 findings from 1 review
Electrical conductance for the detection of dental caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Permanent dentition
Permanent dentition (4 studies): sensitivity ranged from 0.55 to 0.65.
4 studies
GRADE not reported
Electrical conductance for the detection of dental caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Primary dentition
Primary dentition (3 studies): sensitivity ranged from 0.91 to 0.93. No evidence of a difference in accuracy by dentition (removing accuracy covariate: Chi2=3.15, df=1, P=0.08).
3 studies
GRADE not reported
Sensitivity for detection of oral cavity cancer/OPMD · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…
1 finding from 1 review
Summary of findings 4 (no pooled analysis): sensitivity 0.85 (95% CI 0.81 to 0.88), 0.82 (95% CI 0.57 to 0.96), and 0.94 (95% CI 0.70 to 1.00) across the 3 studies. Prevalence 12.2% to 30.9%. Certainty VERY LOW.
3 studies · 3600 participants
Very low
Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
17 findings from 1 review
Show 14 more findings
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Setting: in vitro (non-CBCT)
Specificity 0.89 [0.84, 0.92]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Proximal surfaces (non-CBCT)
Specificity 0.89 [0.84, 0.93]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Primary dentition (non-CBCT)
Specificity 0.87 [0.77, 0.93]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Occlusal surfaces (non-CBCT)
Specificity 0.88 [0.80, 0.93]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Sensitivity analysis: excluding high/unclear risk of bias reference standard
Specificity 0.87 [0.83, 0.90]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Reference standard: excavation (non-CBCT)
Specificity 0.96 [0.80, 0.99]
5 studies
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Dentine-caries (D3) prevalence medium 15-34% (non-CBCT)
Specificity 0.87 [0.78, 0.92]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies)
Specificity 0.88 [0.84, 0.92]
77 studies
Low
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Analogue and digital combined (non-CBCT); 97 datasets
Specificity 0.89 [0.86, 0.92]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Sensitivity analysis: low dentine-caries prevalence <15%
Specificity 0.91 [0.87, 0.94]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Dentine-caries (D3) prevalence low <15% (non-CBCT)
Specificity 0.91 [0.85, 0.95]
Studies not reported
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Setting: in vivo / clinical (non-CBCT)
Specificity 0.89 [0.78, 0.95]
17 studies
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Reference standard: enhanced visual (non-CBCT)
Specificity 0.91 [0.77, 0.97]
8 studies
GRADE not reported
Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies) · Reference standard: histology (non-CBCT)
Specificity 0.88 [0.83, 0.92]
64 studies
GRADE not reported
Restoration failure · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6 to 12 years)
Direct composite resin restoration may leads to higher restoration failure rate compared with amalgam restoration (low certainty).
3 findings from 1 review
Quality of life · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
The review found no eligible studies for this question.
1 finding from 1 review
Restoration survival · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)
Rubber dam isolation and moisture control (alone or with saliva… may leads to higher survival rate of restorations (6 months) compared with cotton rolls (with or without saliva aspiration) (low certainty).
4 findings from 1 review
Show 1 more finding
Sensitivity · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or extracted teeth of…
1 finding from 1 review
Electrical conductance for the detection of dental caries 2021 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies)
CarieScan Pro (3 studies, 244 tooth surfaces): sensitivity ranged from 0.55 to 0.91. No evidence of a difference in accuracy by device type (Chi2=0.05, df=1, P=0.82).
3 studies
GRADE not reported
Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
2 findings from 1 review
Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
It is very uncertain whether sealing using sealant materials changes failure of therapy compared with selective carious tissue removal (selective excavation, SE) (very low certainty).
1 finding from 1 review
Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
Non-selective carious tissue removal and conventional restoration (CR) probably leads to higher failure of therapy compared with stepwise carious tissue removal (SW) (moderate certainty).
2 findings from 1 review
Overall survival, induction platinum + 5-fluorouracil prior to surgery vs surgery alone · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Induction chemotherapy plus locoregional treatment (radiotherapy… showed no clear difference in overall survival, induction platinum + 5-fluorouracil prior to… compared with locoregional treatment (radiotherapy and/or surgery) alone (low certainty).
1 finding from 1 review
Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
It is very uncertain whether selective carious tissue removal (selective excavation, SE) changes failure of therapy compared with hall Technique (sealing with a preformed metal crown) (very low certainty).
2 findings from 1 review