Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

219 questions · 226 findings · 21 reviews

No studies found 31 · 13.7%GRADE not reported 29 · 12.8%Very low 43 · 19%Low 78 · 34.5%Moderate 43 · 19%High 2 · 0.9%

Systemic TXA vs placebo or usual care

Unplanned hospitalizations or readmissions · Percutaneous nephrolithotomy

It is very uncertain whether systemic TXA changes unplanned hospitalizations or readmissions compared with no TXA (placebo or usual care) (very low certainty).

1 finding from 1 review

Intervention not reported

Number of transfused units of red blood cell (RBC) · adult women with advanced EOC undergoing cytoreductive surgery (one randomised trial available)

The intervention showed no clear difference in number of transfused units of red blood cell (RBC) (low certainty).

1 finding from 1 review

Intervention not reported

Rate of RBC transfusion (total number of participants who required at least one unit of red blood cell transfusion) Time: perioperative and postoperative periods · adult women with advanced EOC undergoing cytoreductive surgery (one randomised trial available)

The intervention showed no clear difference in rate of RBC transfusion (total number of participants who required… (low certainty).

1 finding from 1 review

Intervention not reported

Rate of plasma transfusion (total number of participants who required at least one unit of plasma transfusion) Time: perioperative and postoperative periods · adult women with advanced EOC undergoing cytoreductive surgery (one randomised trial available)

The intervention showed no clear difference in rate of plasma transfusion (total number of participants who… (low certainty).

1 finding from 1 review

Intervention not reported

Reoperation (Number of participants with at least one reoperation) Time: perioperative periods · adult women with advanced EOC undergoing cytoreductive surgery (one randomised trial available)

It is very uncertain whether the intervention changes reoperation (Number of participants with at least one reoperation)… (very low certainty).

1 finding from 1 review

Intervention not reported

Readmission (Number of participants with at least one readmission) Time: perioperative periods) · adult women with advanced EOC undergoing cytoreductive surgery (one randomised trial available)

It is very uncertain whether the intervention changes readmission (Number of participants with at least one readmission)… (very low certainty).

1 finding from 1 review

Intervention not reported

Venous thromboembolic events (number of participants with at least one venous thromboembolic events) Time: 5‐week · adult women with advanced EOC undergoing cytoreductive surgery (one randomised trial available)

It is very uncertain whether the intervention changes venous thromboembolic events (number of participants with at least… (very low certainty).

1 finding from 1 review

Intervention not reported

Arterial thromboembolic events (number of participants with at least one venous thromboembolic events) Time: 5‐week · adult women with advanced EOC undergoing cytoreductive surgery (one randomised trial available)

It is very uncertain whether the intervention changes arterial thromboembolic events (number of participants with at least… (very low certainty).

1 finding from 1 review